Volume 22, Issue 15

open access Global reach, higher impact

Volume 22 (15); 2025

Research Papers

Proteogenomic Analysis on RNA m6A Modification-Associated Genes Identifies a Distinct Subgroup with High IGF2BPs Expression Across Cancer Types
Yebin Ryu, Eunhyong Chang, Hayoon Park, Sung-Yup Cho, Joon-Yong An
Int. J. Med. Sci. 2025; 22(15): 3815-3827. doi:10.7150/ijms.115609
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Targeting LC3B/MCL-1 expression by Protodioscin induces autophagy and apoptosis in human glioblastoma cells in vitro and in vivo
Ching-Ting Tai, Yi-Hsien Hsieh, Hsiang-Lin Lee, Pei-Ni Chen, Hui-Ling Chiou, Tsai-Yun Wu, Chia-Liang Lin, Yi-Chen Lin, Chien-Min Chen
Int. J. Med. Sci. 2025; 22(15): 3828-3838. doi:10.7150/ijms.116656
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PRDX3 Promotes Lymph Node Metastasis in Cervical Cancer by Activating NF-κB Signaling Pathway and Anoikis Resistance
Weijia Wen, Jiaying Li, Li Yuan, Yan Liao, Caixia Shao, Dingze Xu, Hongye Jiang, Yuandong Liao, Pan Liu, Chunyu Zhang, Shuzhong Yao, Wei Wang
Int. J. Med. Sci. 2025; 22(15): 3839-3853. doi:10.7150/ijms.118912
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The natural compound n-butylidenephthalide suppresses type II ovarian cancer cell growth by inducing ferroptosis
Shinn-Zong Lin, Chih-Yang Huang, Yueh-Min Lin, Rathinasamy Baskaran, Yu-Jung Lin, Wei-Wen Kuo, Dah-Ching Ding
Int. J. Med. Sci. 2025; 22(15): 3854-3867. doi:10.7150/ijms.114086
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Punching Above Its Weight: A Head-to-Head Comparison of Deepseek-R1 and OpenAI-o1 on Pancreatic Adenocarcinoma-Related Questions
Cheng-Peng Li, Yuan Chu, Wei-Wei Jia, Priska Hakenberg, Flavius Șandra-Petrescu, Christoph Reißfelder, Cui Yang
Int. J. Med. Sci. 2025; 22(15): 3868-3877. doi:10.7150/ijms.118887
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ABCC6 Transporter Contributed to Cisplatin Resistance on Bladder Cancer
Kuang‑Yu Chou, An-Chen Chang, Thomas I‑Sheng Hwang, Te‑Fu Tsai, Chao‑Yen Ho, Hsiu-Wen Liu, David Achudhan, Chih-Hsin Tang, Yen-You Lin
Int. J. Med. Sci. 2025; 22(15): 3895-3905. doi:10.7150/ijms.115487
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Decoding Endoplasmic Reticulum Stress on Chondrocyte Driving Osteoarthritis Development through Integrating Single-Cell and Transcriptomic Profiling
Zhao Zhang, Debin Cheng, Jingyi Dang, Xiaohe Wang, Hongbin Fan, Dong Liu
Int. J. Med. Sci. 2025; 22(15): 3906-3923. doi:10.7150/ijms.119573
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Deep Learning Based on Automated Breast Volume Scanner Images for the Diagnosis of Breast Lesions: A Multicenter Diagnostic Study
Hui Liu, Ying Zhang, Bin Tan, Yi-Fei Yin, Li-Xia Yan, Li-Hua Xiang, Dan-Dan Shan, Yun-Yao Zhang, Shi-Si Ding, Guang Xu, Bo-Yang Zhou, Yi-Lei Shi, Xiao-Xiang Zhu, Jing-Liang Hu, Li-Ping Sun, Hui-Xiong Xu, Yi-Feng Zhang
Int. J. Med. Sci. 2025; 22(15): 3924-3937. doi:10.7150/ijms.118430
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Drug Interaction of Dasatinib with Thymoquinone: A Pharmacokinetic Study in Rats
Ajaz Ahmad, Mohammad Raish, Khalid M. Alkharfy, Yousef A Bin Jardan, Abdul Ahad, Mohd Abul Kalam, Muzaffer Iqbal, Ibrahim A. Abdelrahman, Naushad Ali, Ali Akhtar, Fahad I Al-Jenoobi
Int. J. Med. Sci. 2025; 22(15): 3939-3945. doi:10.7150/ijms.109707
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Potential impact of omentin-1 genetic variants with the clinical features and progression of buccal mucosa cancer
Ya-Hsin Wu, Chiao-Wen Lin, Hsiao-Chi Tsai, Chun-Wen Su, Ming-Yu Lien, Shun-Fa Yang, Chih-Hsin Tang
Int. J. Med. Sci. 2025; 22(15): 3958-3964. doi:10.7150/ijms.117708
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Multidimensional Factors Related to Engagement in Child-to-Parent Violence among Adolescents with Attention-Deficit/Hyperactivity Disorder
Wen-Jiun Chou, Ray C. Hsiao, Peng-Wei Wang, Cheng-Fang Yen
Int. J. Med. Sci. 2025; 22(15): 3965-3973. doi:10.7150/ijms.116091
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Association of Fine Particulate Matter (PM2.5) and Wet-Bulb Globe Temperature (WBGT) with Osteoporosis Incidence: A Nationwide Prospective Cohort Study
En-Che Chang, Fu-Wen Liang, Jiun-Chi Huang, Hao-Han Chang, Shu-Pin Huang, Szu-Chia Chen, Chih-Da Wu, Ya-Chin Huang, Jiun-Hung Geng
Int. J. Med. Sci. 2025; 22(15): 3974-3984. doi:10.7150/ijms.115460
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Environmental Lead Exposure Predicts Lower Bone Mineral Density in a Large Taiwanese Population-Based Study
Po-Yin Shen, Fu-Wen Liang, Cheng-Chang Lu, Shu-Pin Huang, Szu-Chia Chen, Jiun-Hung Geng
Int. J. Med. Sci. 2025; 22(15): 3985-3993. doi:10.7150/ijms.117042
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Cerebrospinal fluid profile in coronavirus disease 2019, a prospective case series study
Huiying Lin, Xiaoli Zhang, Hangfeng Li, Shuangfang Fang, Huapin Huang, Nan Liu, Houwei Du
Int. J. Med. Sci. 2025; 22(15): 3994-4002. doi:10.7150/ijms.111747
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Circulating miRNAs are Down-regulated in Asthmatic Patients; Case-control Study
Christian A. Trejo-Jasso, Héctor Isaac Rocha-González, Eduardo Montes-Martínez, Manuel Castillejos-López, Arnoldo Aquino-Galvez, Dora Patricia Rosete-Olvera, Jose S. Lopez-Gonzalez, Mario Perez-Medina, Martha Patricia Sierra-Vargas, Angeles Carlos-Reyes, Misael O. García-Martin, Jazmín García-Machorro, Angel Camarena, Victor Ruiz
Int. J. Med. Sci. 2025; 22(15): 4003-4012. doi:10.7150/ijms.111022
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Inhibition of autophagy enhances the sensitivity of ciclopirox olamine in human chronic myelogenous leukemia K562 cells
Hongyu Zhou, Hongyan Chen, Kaitao Luo, Lingmei Kong, Yan Li
Int. J. Med. Sci. 2025; 22(15): 4013-4025. doi:10.7150/ijms.114452
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Clinical Efficacy of Topical Ziyun Ointment in Improving Skin Hydration and Reducing Transepidermal Water Loss in Psoriasis
Yu-Ping Hsiao, Wen-Li Ou, Chun-Te Lu, Jiunn-Liang Ko, Chih-Ting Hsu, Sheau-Chung Tang
Int. J. Med. Sci. 2025; 22(15): 4026-4035. doi:10.7150/ijms.118035
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Plasma Proteome Profiling Identifies Biomarkers and Potential Drug Targets for Non-Small Cell Lung Cancer
Minghui Zhao, Xiaoke Di, Yucui Zhao
Int. J. Med. Sci. 2025; 22(15): 4036-4048. doi:10.7150/ijms.107109
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Tetrahydrocurcumin Protects Microglial Cells Against Pseudomonas aeruginosa Lipopolysaccharide-Induced Reactive Oxygen Species Production and Cathepsin B to Activate NLRP3 Inflammasome-Mediated Pyroptosis Via the HO-1 and p38/JNK Pathway
Hui-Wen Lin, Tzu-Chun Chen, Inga Wang, Jui-Hsuan Yeh, Shang-Chun Tsou, Lee Sun, Shih-Chi Chung, Chen-Ju Chuang, Yuan-Yen Chang
Int. J. Med. Sci. 2025; 22(15): 4049-4062. doi:10.7150/ijms.118252
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Exploring the relationship between exercise and diabetes risk in a prediabetes population
Chih-Wei Chiang, Oswald Ndi Nfor, Wen-Yu Lu, Chien-Ning Huang, Yung-Po Liaw
Int. J. Med. Sci. 2025; 22(15): 4077-4084. doi:10.7150/ijms.116287
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CHAF1B: the hidden culprit behind sorafenib resistance in hepatocellular carcinoma
Wenfeng Zhuo, Jiali Zhao, Zhouying Zheng, Shanglin Cai, Guifang Zeng, En Lin, Zirui Bai, Bo Wang, Yingbin Jia, Peiping Li, Jian Li
Int. J. Med. Sci. 2025; 22(15): 4085-4101. doi:10.7150/ijms.118471
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Targeting ORMDL2 in glioblastoma through integrated landscape of high-throughput sequencing and pharmacogenomic analysis
Fitria Sari Wulandari, Chih-Yang Wang, Sachin Kumar, Ngoc Phung Ly, Juan Lorell Ngadio, Dahlak Daniel Solomon, Do Thi Minh Xuan, Gabriela Natasha Sutandi, Hung-Yun Lin, Hui-Ru Lin, Yung-Kuo Lee, Hao-Chien Yang, Ming-Cheng Tsai, Ching-Chung Ko
Int. J. Med. Sci. 2025; 22(15): 4102-4118. doi:10.7150/ijms.116954
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Study on Predictive Models for Differential Diagnosis of Diabetic Kidney Disease and Non-Diabetic Kidney Disease Based on Clinical and Biochemical Indicators
Pinning Feng, Xianlian Deng, Wenjia Gan, Yijiang Song, Yuyan Yang, Ruijie Zhang, Jin Li, Wenbin Lin
Int. J. Med. Sci. 2025; 22(15): 4119-4130. doi:10.7150/ijms.115709
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Real-World Safety of Anti-EGFR Antibodies: 20-Year Pharmacovigilance of Cetuximab and Panitumumab
Liang-Yan Jin, Guo-Quan Chen, Jun Xie, Ping Chen, Hua-Yu Sun, Hong-Liang Zheng, Liu-Cheng Li, Kai-Li Mao
Int. J. Med. Sci. 2025; 22(15): 4131-4144. doi:10.7150/ijms.122194
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Effects of a Taekwondo-Specific High-Intensity Interval Training Protocol on the Biomarkers of Cardiovascular and Biochemical Recovery in Collegiate Athletes
Po-Teng Huang, Chih-Han Wu, Po-Fang Huang, Ming-Chin Tsai, Kuei-Ling Chang, Kun-He Lin, Hsing-Chieh Huang, Shu-Cheng Lin
Int. J. Med. Sci. 2025; 22(15): 4145-4151. doi:10.7150/ijms.115788
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Impact of Adiposity on Cardiopulmonary Fitness in Children and Adolescents with Ventricular Septal Defects: a CPET-Based Comparative Study
I-Hsiu Liou, Guan-Bo Chen, Shu-Fen Sun, Ruei-Sian Ding, Wan-Yun Huang, Sheng-Hui Tuan
Int. J. Med. Sci. 2025; 22(15): 4152-4160. doi:10.7150/ijms.121548
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Reviews

Association between Disorders of Lipid Metabolism and Oculopathy: An Overview
Yuanting Yang, Ruixue Zhang, Miao Zhang, Zhaohui Yang, Zhongyu Ma, Yinqiao Zhang, Mengke Wu, Dadong Guo, Hongsheng Bi
Int. J. Med. Sci. 2025; 22(15): 3878-3894. doi:10.7150/ijms.116512
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The Application of Epicardium in Heart Failure Treatment: Opportunities and Challenges
Chenlei Zhou, Yaping Xu, Zhikun Guo
Int. J. Med. Sci. 2025; 22(15): 3946-3957. doi:10.7150/ijms.118408
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The Role of Calcium Signaling in Sensorineural Hearing Loss
Yun Hu, Juanjuan Li, Li Tian, Peng Zhang, Xianhai Zeng
Int. J. Med. Sci. 2025; 22(15): 4063-4076. doi:10.7150/ijms.119492
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Erratum

CEMIP as a potential biomarker and therapeutic target for breast cancer patients: Erratum
Jinqi Xue, Xudong Zhu, Xinbo Qiao, Yulun Wang, Jiawen Bu, Xiaoying Zhang, Qingtian Ma, Lu Liang, Lisha Sun, Caigang Liu
Int. J. Med. Sci. 2025; 22(15): 3938. doi:10.7150/ijms.114765
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