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Volume 23 (1); 2026

Research Papers

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Deubiquitomic and bioinformatic analyses in cisplatin-treated lung cancer cells Sun-Kyu Jin, Tae-Woo Kim, Hae-Seul Choi, Chae-Won Lee, Kwang-Hyun Baek Int. J. Med. Sci. 2026; 23(1): 1-11. doi:10.7150/ijms.120464 Full text PDF PubMed PMC

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FGF-23 facilitates osteosarcoma metastasis by modulating the miR-4463/LOXL2 axis expression via the ERK, p38, and JNK signaling pathway Chun-Han Hou, Chih-Yang Lin Int. J. Med. Sci. 2026; 23(1): 12-25. doi:10.7150/ijms.118423 Full text PDF PubMed PMC

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Tumor-Derived CXCL10 and CCL20 Polarize the Immune Microenvironment in Nasopharyngeal Carcinoma via Competitive Recruitment of Effector T Cells and Tregs Benjian Zhang, Xiaotian Yuan, Lai Meng, Yunqing Liu, Yaxuan Wang, Zirong Chen, Haoxiang Zeng, Xinyue Zhang, Zhouying Peng, Hua Zhang, Weihong Jiang Int. J. Med. Sci. 2026; 23(1): 26-41. doi:10.7150/ijms.116010 Full text PDF PubMed PMC

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Amelioration of contusion-induced muscle injury via regulation of the NLRP3 inflammasome Yen-Peng Lee, Chien-Chao Chiu, Liang-Ju Chiu, Yi-Hsun Chen, Wen-Ching Huang Int. J. Med. Sci. 2026; 23(1): 42-52. doi:10.7150/ijms.119730 Full text PDF PubMed PMC

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Sex-Specific Associations Between Hyperuricemia and Kidney Stone Disease in a Large Taiwanese Cohort Meng-Shiang Liu, Shuo-Hung Wang, Jia-In Lee, Szu-Chia Chen, Shu-Pin Huang, Jiun-Hung Geng Int. J. Med. Sci. 2026; 23(1): 53-62. doi:10.7150/ijms.109742 Full text PDF PubMed PMC

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Academic Career Pathways in German Medicine: Current Structures and International Comparisons Markus Strauss, Sarah Altenberger, Jan Peter Ehlers Int. J. Med. Sci. 2026; 23(1): 76-88. doi:10.7150/ijms.118738 Full text PDF PubMed PMC

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Acute Exercise Effects on Cognitive Flexibility in Preterm and Full-Term Children: An Event-Related Potential Study Feng-Tzu Chen, Pei-Chen Hsiao, Charles H. Hillman, Sheng-Hsien Feng, Chien-Heng Chu, Yu-Kai Chang Int. J. Med. Sci. 2026; 23(1): 89-99. doi:10.7150/ijms.120694 Full text PDF PubMed PMC

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Lymphoma-Associated Bone Marrow Hemophagocytosis (LA-BMHPC): A Retrospective, Single-Center Study of 67 Patients Feiyang Zong, Renjie Hua, Meng Dong, Xudong Zhang, Honghan Qiao, Sijun Zhang, Yukai Duan, Qingjiang Chen Int. J. Med. Sci. 2026; 23(1): 100-112. doi:10.7150/ijms.115901 Full text PDF PubMed PMC

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Decoding Short- and Long-Term Cellular Adaptations to Cr(VI) Exposure Through High-Throughput Transcriptomics I-Jeng Yeh, Chih-Yang Wang, Nam Nhut Phan, Do Thi Minh Xuan, Ching-Chung Ko, Sachin Kumar, Dahlak Daniel Solomon, A-Mei Huang, Meng-Chi Yen, Cheng-Che E. Lan Int. J. Med. Sci. 2026; 23(1): 113-125. doi:10.7150/ijms.119668 Full text PDF PubMed PMC

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Betel-quid Use Is Associated with Depression Perl Han Lee, Jiun-Hung Geng, Szu-Chia Chen, Chien-Hung Lee, Chih-Hung Ko Int. J. Med. Sci. 2026; 23(1): 126-132. doi:10.7150/ijms.119520 Full text PDF PubMed PMC

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Similarities and differences between Alzheimer's disease and schizophrenia: drug target Mendelian randomization and transcriptome analysis Yuping Zhang, Ju Shao, Bibo Liang, Yihong He, Zhixin Wen, Bo Cai, Ligang Jie Int. J. Med. Sci. 2026; 23(1): 133-145. doi:10.7150/ijms.119636 Full text PDF PubMed PMC

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Predicting ICU mortality in patients with abdominal aortic aneurysm: a nomogram based on MIMIC-IV and eICU-CRD Mengwei He, Xiang Zhang, Weixue Huo, Jin Qu, Sen Wang, Zhaoxiang Zeng, Lushun Yuan, Rui Feng Int. J. Med. Sci. 2026; 23(1): 146-160. doi:10.7150/ijms.116265 Full text PDF PubMed PMC

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Integrative analysis identifies PIGK as an oncogenic glycosylphosphatidylinositol transamidase subunit with prognostic, immunological, and therapeutic relevance in head and neck cancer Yi-Fang Yang, Jia-Bin Liao, Pei-Lun Yu, Chih-Yu Chou, Yu-Hsuan Lin Int. J. Med. Sci. 2026; 23(1): 161-176. doi:10.7150/ijms.121484 Full text PDF PubMed PMC

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SF3A2: a promising therapeutic target and predictive biomarker for immunotherapy in colorectal cancer Changjiang Yang, Shidong Zhao, Long Zhao, Yuanpei Lin, Yingjiang Ye, Caihong Wang, Zhanlong Shen Int. J. Med. Sci. 2026; 23(1): 177-193. doi:10.7150/ijms.123448 Full text PDF PubMed PMC

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Anti-inflammatory activity of α-tomatine via inhibition of the MAPK and NF-κB signaling pathway in vitro and ex vivo Chien-Wei Chen, Chu-Chun Hsieh, Yi-Ting Hsieh, Ming-Ju Lin, Po-Hao Chiu, Chi-Chang Juan, Fu-Kong Lieu, Shyi-Wu Wang, Paulus S. Wang Int. J. Med. Sci. 2026; 23(1): 194-203. doi:10.7150/ijms.118250 Full text PDF PubMed PMC

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Thrombospondin-4 drives lymphangiogenesis through cooperation with VEGF-C in human bladder cancer Thomas I-Sheng Hwang, Pei-Wen Peng, Mau-Shin Chi, Kuang-Yu Chou, Te-Fu Tsai, Chao-Yen Ho, An-Chen Chang Int. J. Med. Sci. 2026; 23(1): 204-215. doi:10.7150/ijms.122895 Full text PDF PubMed PMC

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A Blurred Vision of Health: Metabolic Syndrome as a Risk Factor for Glaucoma in a Large Taiwanese Population Study Sheng-Hao Chang, Jia-In Lee, Szu-Chia Chen, Shu-Pin Huang, Jiun-Hung Geng Int. J. Med. Sci. 2026; 23(1): 216-226. doi:10.7150/ijms.121641 Full text PDF PubMed PMC

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The Sleep Connection: Exploring the Role of Composite Dietary Antioxidant Index in Sleep Quality Based on NHANES 2007-2014 Xiang Xu, Xin Wei, Hong Chen, Hao Gao, XingHua Chen Int. J. Med. Sci. 2026; 23(1): 227-242. doi:10.7150/ijms.114874 Full text PDF PubMed PMC

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Oral administration of soybean okara extract reduces osteoarthritis pain and progression in rats Kun-Tsan Lee, Chien-Min Chen, Chih-Hsin Tang, Yen-You Lin, Tzu-Ching Chang, Min-Huan Wu, Sunny Li-Yun Chang Int. J. Med. Sci. 2026; 23(1): 243-252. doi:10.7150/ijms.123212 Full text PDF PubMed PMC

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Integration of Single-cell and Bulk Transcriptome Analyses Unravels a Macrophage-based Gene Signature for Prognostication and Treatment in Triple-negative Breast Cancer Yuan Huang, Yuan Yu, Yufei Zhu, Qianhui Lu, Ziwen Zhang, Xiaojia Wang, Xiaowei Wang, Yabing Zheng Int. J. Med. Sci. 2026; 23(1): 253-270. doi:10.7150/ijms.120593 Full text PDF PubMed PMC

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Real-World Efficacy of Transarterial Embolization and Transarterial Chemoembolization in Unresectable Hepatocellular Carcinoma: a Nationwide Cohort Study in Taiwan Yu-Han Huang, Ping-Jen Hu, Sung-Hua Chiu, Wei-Chou Chang, Yuh-Feng Lin, Po-Ya Chang Int. J. Med. Sci. 2026; 23(1): 283-292. doi:10.7150/ijms.119821 Full text PDF PubMed PMC

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The Efficacy and Safety of Thiopurines Do Not Differ Between Geriatric and Non-Geriatric Patients with Inflammatory Bowel Disease Derya Arı, Kerem Kenarlı, Ferhat Bacaksız, Sinan Arı, Volkan Gökbulut, Ömer Öztürk, Yasemin Özderin Özin, İsmail Hakkı Kalkan Int. J. Med. Sci. 2026; 23(1): 293-300. doi:10.7150/ijms.116202 Full text PDF PubMed PMC

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WISP-3 facilitates CCL4-dependent monocyte migration and M1 polarization in rheumatoid arthritis by inhibiting miR-6894-5p Guo-Shou Wang, Kun-Tsan Lee, Syuan-Ling Lin, Sheng-Mou Hou, Yi-Chin Fong, Chih-Hsin Tang, Chih-Yang Lin Int. J. Med. Sci. 2026; 23(1): 301-312. doi:10.7150/ijms.122642 Full text PDF PubMed PMC

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Comparative analysis of two analytical methodologies for deriving dietary patterns associated with vitamin D insufficiency and anemia among expectant mothers Arpita Das, Chien-Yeh Hsu, Chyi-Huey Bai, Jung-Su Chang, Ya-Li Huang, Fan-Fen Wang, Nhi Thi Hong Nguyen, Yi-Chun Chen, Jane C.-J. Chao Int. J. Med. Sci. 2026; 23(1): 325-333. doi:10.7150/ijms.124006 Full text PDF PubMed PMC

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Kisspeptins inhibit ectopic endometrial cell invasion and angiogenesis by suppressing PI3K/AKT signaling pathway via CREB5 in endometriosis Lingnan Kong, Suliya Yushanjiang, Li Nie, Yiran Pan, Lei Jin, Zun Wang, Man He, Gao Zhang, Ziyang Ma, Rongqian Zhao, Dongzhi Yuan, Changlong Li Int. J. Med. Sci. 2026; 23(1): 334-349. doi:10.7150/ijms.112890 Full text PDF PubMed PMC

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Ubiquitin D Correlates with Disease Severity and T Cell Infiltration in Cholestasis: Evidence from Integrated Bioinformatics and Experimental Analyses Huiwen Wang, Jian Zhang, Xun Huang, Shifang Peng Int. J. Med. Sci. 2026; 23(1): 350-362. doi:10.7150/ijms.122687 Full text PDF PubMed PMC

Reviews

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Tumor-Promoting Gut Microbes in Colorectal Cancer: Mechanisms and Translational Perspectives Yulong Yu, Weiheng Zhao, Mu Yang, Bili Wu, Xianglin Yuan Int. J. Med. Sci. 2026; 23(1): 63-75. doi:10.7150/ijms.123494 Full text PDF PubMed PMC

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Polycystic Ovary Syndrome Revisited: Novel Insights and Updates Wenwen Zhao, Jiayi Zhou, Yanhua Song, Miao He, Xudong Zhu, Bianfang Yu, Wenxiao Gao Int. J. Med. Sci. 2026; 23(1): 271-282. doi:10.7150/ijms.119968 Full text PDF PubMed PMC

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Role of Circular RNAs in Liver Diseases Badr Alzahrani Int. J. Med. Sci. 2026; 23(1): 313-324. doi:10.7150/ijms.124473 Full text PDF PubMed PMC

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