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Volume 23 (10); 2026

Research Papers

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Haloperidol Triggers RAW264.7 Macrophages Injury through Oxidative Stress-Driven Mitochondrial Dysfunction, Genomic Instability, and Apoptotic Cell Death Yen-Ju Lee, Yen-Po Chen, Wan-Yun Hsu, Serena-Haining Shay, Ping-Kun Tsai, Chun-Hung Su, Shih-Pin Chen, Sheng-Wen Wu, Chen-Yu Chiang, Yu-Hsiang Kuan Int. J. Med. Sci. 2026; 23(10): 3066-3078. doi:10.7150/ijms.135133 Full text PDF


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Isoalantolactone Attenuates LPS-Induced Acute Lung Injury, an Effect Associated with Suppressed MAPK/STAT3 Activation and Epithelial-Mesenchymal Transition Chia-Yang Li, Chung-Wei Liu, Hsin-Han Tseng, Yu-Hsin Tseng, Shu-Chi Wang, Po-Len Liu, Hsin-En Wu, Yuan-Ru Chen, Sheng-I Lee, Tzu-Chieh Lin, Ching-Tang Chang, Xin-Yi Lin, I-Chen Chen Int. J. Med. Sci. 2026; 23(10): 3079-3089. doi:10.7150/ijms.126267 Full text PDF


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Interplay between Skin Sympathetic Nerve Activity and Gut Microbiota, the Neurocardiac Axis in Acute Coronary Syndrome Wei-Chung Tsai, Po Peng, Pei-Syuan Jhou, Yi-Chun Tsai, Wei-Wen Hung, Tien-Chi Huang, Li-Fang Chou, Tsung-Hsien Lin, Chien-Hung Lee, Bin-Nan Wu, Shien-Fong Lin, Wei-Chun Hung Int. J. Med. Sci. 2026; 23(10): 3090-3100. doi:10.7150/ijms.126417 Full text PDF


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Validation of Osteoporosis associated SNPs candidates from Decisive Gene Strategy using Taiwan Biobank Pei-Jan Tsai, Sin-Yu Lin, Meng-Chang Lee, Mei-Jung Chen, Chih-Chien Wang, Cheng-Jung Chen, Wei-Teing Chen, Po-Jen Hsiao, Chih-Chien Chiu, Yu-Hsuan Chen, Hsiao-Ting Lin, Hao Su, Sui-Lung Su Int. J. Med. Sci. 2026; 23(10): 3122-3133. doi:10.7150/ijms.125797 Full text PDF


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Target-Specific Extracorporeal Shockwave Therapy Modulates TLR4/NF-κB/MMP13 Signaling Within the Joint Microenvironment to Improve Osteochondral Pathology in Patellofemoral Osteoarthritis Shun-Wun Jhan, Kuan-Ting Wu, Wen-Yi Chou, Po-Cheng Chen, Wen-Chiung Huang, Jai-Hong Cheng Int. J. Med. Sci. 2026; 23(10): 3134-3147. doi:10.7150/ijms.132904 Full text PDF


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Age-Related Differences in Clinical and Surgical Outcomes Following Oblique Lateral Interbody Fusion: A Retrospective Cohort Study Yun-Che Wu, Cheng-Hung Lee, Jun-Sing Wang, Meng-Jen Lee Int. J. Med. Sci. 2026; 23(10): 3148-3155. doi:10.7150/ijms.127252 Full text PDF


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Mulberry Leaf Extracts and Neochlorogenic Acid Ameliorated Scopolamine-induced Cognitive Dysfunction through Promotion of Adult Hippocampal Neurogenesis Li-Sung Hsu, Yi-Ling Cheng, Yun-Ching Chang, Yi-Ju Lee, Chau-Jong Wang Int. J. Med. Sci. 2026; 23(10): 3156-3168. doi:10.7150/ijms.136787 Full text PDF


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Cross-Species Identification of Urinary Small Extracellular Vesicle-Associated miR-223-3p as a Candidate Biomarker for Nephrolithiasis in a Discovery Cohort Bo-Jung Chen, Jang Jeong Uk, Cheng-Huang Shen, Chiung-Yao Fang, Ya-Yan Lai, Yu-Wen Hong, Chi-Yang Eaw, Mei-Chiao Chuang, Jui-Chieh Chen Int. J. Med. Sci. 2026; 23(10): 3169-3182. doi:10.7150/ijms.136918 Full text PDF


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Effectiveness of Structured Skin Care Using Silicone Barrier Spray Compared with Zinc Oxide Ointment for Incontinence-Associated Dermatitis in Long-Term Care Residents: A Randomized Controlled Trial Po-Chung Chen, Chi-Ming Chu, Po-Jen Hsiao, Hsieh-Chih Tsai Int. J. Med. Sci. 2026; 23(10): 3183-3193. doi:10.7150/ijms.132180 Full text PDF


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Risk of Venous Thromboembolism in Patients with Presumed Primary Raynaud's Syndrome: A Propensity-Matched Study Using the TriNetX Database Shang-Hsuan Huang, Chao-Bin Yeh, Yu-Hsun Wang, Shun-Fa Yang, Ying-Cheng Chen Int. J. Med. Sci. 2026; 23(10): 3211-3219. doi:10.7150/ijms.139691 Full text PDF


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Association of Preoperative Pan-Immune-Inflammation Value with Adverse Pathology and Oncological Outcomes Following Radical Prostatectomy: A Single-Center Retrospective Study Tsz-Yi Tang, Hao-Han Chang, Yung-Shun Juan, Yung-Chin Lee, Chia-Yang Lee, Jiun-Hung Geng, Shu-Pin Huang Int. J. Med. Sci. 2026; 23(10): 3220-3227. doi:10.7150/ijms.139320 Full text PDF


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Frailty increases vulnerability to postoperative cognitive dysfunction following general anesthesia in aged rats Eun-Hwa Cho, Tae-Hoon Kim, Seung-Wan Hong, Eun-Hye Seo, Seong-Hyop Kim Int. J. Med. Sci. 2026; 23(10): 3228-3236. doi:10.7150/ijms.139225 Full text PDF


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Metformin-Functionalized Selenium Nanoparticles Restore Insulin Signaling and Metabolic Homeostasis in Letrozole-Induced Polycystic Ovary Syndrome Rat Model Uğur Ermis, Damla Binentoglu, Erdem Toktay, Huseyin Fatih Gul, Hasan Ilhan, Muhammed Yayla Int. J. Med. Sci. 2026; 23(10): 3237-3251. doi:10.7150/ijms.135170 Full text PDF


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Cytomegalovirus Infection Is Associated with Increased Disease Activity and Worse Long-Term Course in Ulcerative Colitis Richard Vollenberg, Benedikt Blömer, Clara Zippel, Markus Strauss, Eva Lorentzen, Jonel Trebicka, Phil-Robin Tepasse Int. J. Med. Sci. 2026; 23(10): 3262-3270. doi:10.7150/ijms.139439 Full text PDF


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Habitual tea consumption is associated with a low prevalence of gastroesophageal reflux disease in a Taiwanese population study Cheng-Ming Kuo, Jiun-Hung Geng, Wen-Hung Hsu, Neng-Shen Chu, Szu-Chia Chen Int. J. Med. Sci. 2026; 23(10): 3271-3280. doi:10.7150/ijms.139922 Full text PDF


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Association between FNDC5 Deficiency and Compromised Mitochondrial Integrity and Biogenesis in Kidney Disease Chien-Wei Huang, Chia-Jung Li, Junne-Ming Sung, Yau-Sheng Tsai, Jin-Shuen Chen Int. J. Med. Sci. 2026; 23(10): 3281-3295. doi:10.7150/ijms.130226 Full text PDF

Reviews

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Potential Role of Red Yeast Rice in the Prevention and Treatment of Alzheimer's Disease Qining Quan, Ronghua Pan, Haolin Liu, Lizhong Zheng, Rui Zhang Int. J. Med. Sci. 2026; 23(10): 3101-3111. doi:10.7150/ijms.135847 Full text PDF


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Roles of GDF-15 in Acute Heart Failure: from Mechanistic Insights to Clinical Applications Paisit Kosum, Nonthikorn Theerasuwipakorn, Siriporn C. Chattipakorn, Nipon Chattipakorn Int. J. Med. Sci. 2026; 23(10): 3112-3121. doi:10.7150/ijms.138771 Full text PDF


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Hyperbaric Oxygen Therapy for Cognitive Impairment Resulting from Neurological Disorders: Mechanisms of Action and Application Advances Tianjiao Wei, Wenhui Gu, Lisha Ye, Guohua Wang Int. J. Med. Sci. 2026; 23(10): 3194-3210. doi:10.7150/ijms.128159 Full text PDF


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Progress and Practice of Insulin Resistance in Pregnancy: From Pathogenesis to Management Ya Zhu, Hui Gu, Ping Li Int. J. Med. Sci. 2026; 23(10): 3252-3261. doi:10.7150/ijms.136420 Full text PDF

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