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Volume 23 (4); 2026

Research Papers

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Inhibitory effects of patchouli alcohol on hepatocellular carcinoma growth through accumulation of oxidative stress and inactivation of androgen receptor signaling
Xiao-Fan Huang, Kai-Fu Chang, Nu-Man Tsai
Int. J. Med. Sci. 2026; 23(4): 1174-1189. doi:10.7150/ijms.123787
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Fermented Clostridium butyricum GKB7 Inhibits Osteoarthritis Induced by Anterior Cruciate Ligament Transection in a Preclinical Model
Wei-Cheng Chen, Li-Chai Chen, You-Shan Tsai, Yen-Po Chen, Yen-Lien Chen, Chin-Chu Chen, Yen-You Lin, Tzu-Ching Chang, Chen-Ming Su, Chih-Hsin Tang
Int. J. Med. Sci. 2026; 23(4): 1190-1197. doi:10.7150/ijms.126850
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Integrated analysis uncovers KCMF1 genetic susceptibility and the SNRPD2 axis in renal cell carcinoma
Jiunn-Bey Pao, Yu-Mei Hsueh, Pei-Ling Chen, Tzu-Hao Huang, Chia-Yang Li, Jiun-Hung Geng, Te-Ling Lu, Chao-Yuan Huang, Shu-Pin Huang, Bo-Ying Bao
Int. J. Med. Sci. 2026; 23(4): 1198-1208. doi:10.7150/ijms.129880
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Development and Validation of Novel Senescence-TIME Biomarkers for Predicting the Prognosis and Immunotherapy Responsiveness of SKCM Patients
Shiying Fan, Shuya Lu, Zilong Wu, Xu Li, Yisong Gao, Gan Mao, Mao Cai, Tianyu Song, Zuojie Peng, Chong Li, Kaixiong Tao, Wei Li
Int. J. Med. Sci. 2026; 23(4): 1209-1224. doi:10.7150/ijms.127285
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Enhanced Scar Reduction Using Topical Application of Captopril-containing Silicone Gel in a Rabbit Model of Hypertrophic Scars
Jeeyoon Kim, Hyun-mu Jo, Jongweon Shin, Eun Young Rha
Int. J. Med. Sci. 2026; 23(4): 1234-1242. doi:10.7150/ijms.123608
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IDH1 mutation creates a dependency on fatty acid metabolism that underlies sensitivity to cuproptosis in acute myeloid leukemia cells
Xuening Zhang, Dayuan Zheng, Tong Chu, Dongfan Yang, Kuanyun Zhang, Shaokui Liang, Lu Yang, Wenzhe Ma
Int. J. Med. Sci. 2026; 23(4): 1243-1256. doi:10.7150/ijms.127886
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Association of NUCB2 genetic variants with the clinicopathological features of oral cancer
Chang-Chiang Yu, Hsueh-Ju Lu, Ming-Yu Lien, Chiao-Wen Lin, Jian-Hong Yu, Shun-Fa Yang, Chih-Hsin Tang
Int. J. Med. Sci. 2026; 23(4): 1257-1263. doi:10.7150/ijms.129479
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Expression of ubiquitin carboxyl-terminal hydrolase isozyme L1 and chromogranin A regulated via histone-modification through Rho/ERK/NFκB signaling in oxaliplatin-resistant colorectal cancer cells
Ko-Chao Lee, Kung-Chuan Cheng, Cheng-Yi Huang, Meng-Chiao Hsieh, Shui-Yi Tung, Yung-Yu Hsieh, Kam-Fai Lee, Chih-Chuan Teng, Hsing-Chun Kuo
Int. J. Med. Sci. 2026; 23(4): 1264-1277. doi:10.7150/ijms.126460
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Association of MIAT genetic variants and expression with tumor grade in oral tongue cancer
Ping-Ju Chen, Chiao-Wen Lin, Chun-Yi Chuang, Shun-Fa Yang, Ying-Erh Chou
Int. J. Med. Sci. 2026; 23(4): 1278-1284. doi:10.7150/ijms.129445
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Non-Coding DNA-Derived Mimotopes of Aβ₄₂ as Novel Candidates for Alzheimer's Peptide Vaccine Design
Navya Raj, Shidhi P. R, Rebai Ben Ammar, Peramaiyan Rajendran, Biju Vadakkemukadyil Chellappan
Int. J. Med. Sci. 2026; 23(4): 1320-1332. doi:10.7150/ijms.127358
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Single-cell Profiling Reveals Cooperative Participation of SPP1+ Myeloid and POSTN+ Fibroblast Subsets in Inflammation and Remodeling in Thoracic Aortic Aneurysm
Yingjiao Ju, Jingyi Yao, Song Zhang, Jiangxu Wu, Jiongao Xiang, Li Min, Mingyuan Liu
Int. J. Med. Sci. 2026; 23(4): 1333-1355. doi:10.7150/ijms.124136
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Synergistic Anticancer Effects of Lenvatinib Combined with N-butylidenephthalide in Human Colorectal Cancer Cells
Cheng-Chan Yu, Sung-Ying Huang, Shu-Fang Chang, Yu-Hung Kuo, Kuan-Fu Liao, Sheng-Chun Chiu
Int. J. Med. Sci. 2026; 23(4): 1356-1368. doi:10.7150/ijms.122381
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The efferocytosis-related genes of SLC26A6, TYRO3, and PDK4 have been identified as predictors of prognosis in hepatocellular carcinoma and are associated with the immune status
Jiao-Jiao Yang, Qing Ouyang, Xin-Xin Zeng, Wen-Jian Cen, Ling Deng, Gao-Ping Song, Fang Wang, Li-Yue Sun
Int. J. Med. Sci. 2026; 23(4): 1369-1394. doi:10.7150/ijms.120781
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Key statistical recommendations for medical journals: insights from the Global Burden of Disease Study Collaborators
Michal Ordak
Int. J. Med. Sci. 2026; 23(4): 1395-1407. doi:10.7150/ijms.119771
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Integrative Multi-Omics and Single-Cell Analysis Reveal THOC3 and THOC7 as Oncogenic RNA Processing Regulators in Lung Adenocarcinoma
Sachin Kumar, Chung-Che Wu, Dahlak Daniel Solomon, Meng-Chi Yen, I-Jeng Yeh, Ching-Chung Ko, Do Thi Minh Xuan, Kai-Fu Chang, Hui-Ru Lin, Hung-Yun Lin, Chia-Lung Shih, Jian-Bin Chen, Wei-Yi Lee, Chih-Yang Wang, Yung-Kuo Lee, Ngoc Uyen Nhi Nguyen
Int. J. Med. Sci. 2026; 23(4): 1408-1430. doi:10.7150/ijms.128975
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Association of Glucagon-like Peptide-1 Receptor Agonists with Mortality and Aspiration Pneumonia in Patients with Type 2 Diabetes After Gastrostomy: A Target Trial Emulation Study
Yuan-Tsung Tseng, Chung-Hung Chen, Li-Ping Chou, Shu-Ying Chen, Huai-Yi Huang, Jyun-Wei Wang, Chung-Yi Li
Int. J. Med. Sci. 2026; 23(4): 1444-1455. doi:10.7150/ijms.128956
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Beyond Conventional Analgesics: Updated Evidence Supporting Botulinum Toxin Type A for-Neuralgia Management
Jui-Ting Yu, Chen-Pi Li, Tsai-Mei Huang, Ru-Yin Tsai
Int. J. Med. Sci. 2026; 23(4): 1456-1469. doi:10.7150/ijms.130934
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Longitudinal Radiological Remodeling after Irreversible Electroporation Versus Radiofrequency Ablation: A Prospective Comparative Study (The LIRA Study)
Yiting Liu, Qin Liu, Haiyang Yu, Wei Huang, Ziyin Wang, Qingbing Wang, Jingjing Liu, Xiaoyan Fei, Junwei Gu, Zhongmin Wang, Xiaoyi Ding, Zhiyuan Wu
Int. J. Med. Sci. 2026; 23(4): 1470-1481. doi:10.7150/ijms.133300
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Association of retinal microvascular abnormalities with cardiovascular diseases in patients with severe carotid artery stenosis
Li Zhang, Qi-Bo Ran, Chun-Yan Lei, Fei-Peng Jiang, Tian-Yu Yang, Zhi-Hao Xiao, Sheng Gao, Mei-Xia Zhang
Int. J. Med. Sci. 2026; 23(4): 1482-1490. doi:10.7150/ijms.126670
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Metabolomics Reveals the Anti-hepatic Fibrosis Mechanisms of Pueraria lobata (Willd.) Ohwi Extract and Potential Metabolites Alterations
Yu-Ju Chen, Lo-Yun Chen, Ngoc-Thac Pham, John Louie Dela Vega, Federica Fulgheri, Ching-Chiung Wang, Maria Letizia Manca, Chia-Jung Lee
Int. J. Med. Sci. 2026; 23(4): 1491-1508. doi:10.7150/ijms.129139
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New-onset renal diseases after total knee arthroplasty in patients with osteoarthritis: a multicenter retrospective cohort study
Shiu-Jau Chen, Hsin-Yo Lu, Chih-Lung Wu, Chun-Wei Lin, Hui-Chin Chang, Shuo-Yan Gau
Int. J. Med. Sci. 2026; 23(4): 1509-1518. doi:10.7150/ijms.121331
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Magnesium Oxide Use and Clinical Outcomes in CKD Patients: Evidence from a Nationwide Population-Based Cohort Study in Taiwan
Po-Jen Hsiao, Liam Li-An Tsou, Chung-Chi Yang, Li-Yen Huang, Ruei-Lin Wang, Jenq-Shyong Chan, Kun-Lin Wu, Yung-Hsi Kao, Chu-Lin Chou
Int. J. Med. Sci. 2026; 23(4): 1519-1534. doi:10.7150/ijms.125059
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Cisplatin Induces Inflammation by Activating IL-6 via Suppressing rno-let-7g-5p and rno-let-7f-5p Expression in Intestinal Epithelial Cells
Chi-Jen Chang, Tsung-Ming Chang, Ying-Sui Sun, Kuan-Ting Lu, Ju-Fang Liu
Int. J. Med. Sci. 2026; 23(4): 1554-1566. doi:10.7150/ijms.131043
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Betulin inhibits inflammatory factors synthesis in osteoarthritis synovial fibroblasts by suppressing the PI3K, Akt, and mTOR pathways and activating miR-5006-5p
Kun-Tsan Lee, Chun-Hao Tsai, Yu-Han Wang, Xiu-Yuan He, Yi-Chin Fong, Chih-Yuan Ko, Chih-Hsin Tang
Int. J. Med. Sci. 2026; 23(4): 1567-1576. doi:10.7150/ijms.130493
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Risk of peripheral vestibular disorders and hearing impairment among users of glucagon-like peptide-1 receptor agonists
Jing-Yang Huang, Yen-Ting Lu, Chung-Han Hsin, Tun-Shin Lo, Chia-Yi Lee, Shun-Fa Yang, Miao-Yu Liao
Int. J. Med. Sci. 2026; 23(4): 1577-1587. doi:10.7150/ijms.131397
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Reviews

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Posterior placenta accreta spectrum: unraveling distinctive clinical features and diagnostic challenges
Yating Wu, Kuifang Shen, Caihong Hu, Jianling Wei, Jingrui Huang, Chenlin Pei
Int. J. Med. Sci. 2026; 23(4): 1225-1233. doi:10.7150/ijms.127179
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CYP450 Constraints in Infants: A Multidomain Convergence Framework for Investigating Mechanistic Vulnerability
Gary S. Goldman
Int. J. Med. Sci. 2026; 23(4): 1285-1319. doi:10.7150/ijms.129127
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Atropine Eye Drops in Childhood Myopia Control: A Review
Qin Zhu, Yanhua Chen, Xuejiao Li, Liping Xue, Xiaofan Zhang, Guanglong Zhou, Yuan Zhou, Jieying Zhang, Allison Wilde, Yingting Zhu, Yuezu Li
Int. J. Med. Sci. 2026; 23(4): 1431-1443. doi:10.7150/ijms.126651
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The Multi-dimensional Mechanisms and Transformation Prospects of the Intratumoral Microbiota-Arginine Metabolism Axis in Tumor Progression and Immune Regulation
Shuyang Yu, Jinhua Chen, Wan Shu, Guanxiao Chen, Xiaoyu Shen, Shuangshuang Cheng, Kejun Dong, Hongbo Wang
Int. J. Med. Sci. 2026; 23(4): 1535-1553. doi:10.7150/ijms.128450
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