Int J Med Sci 2014; 11(3):268-275. doi:10.7150/ijms.7769 This issue
1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health.
2. Key Laboratory of Organ Transplantation, Zhejiang Province.
3. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
* These authors contributed equally to this work.
Background: Metastasis-associated in colon cancer-1 (MACC1) acts as a promoter of tumor metastasis; however, the predictive value of MACC1 for hepatocellular carcinoma (HCC) after liver transplantation (LT) remains unclear.
Methods: We examined the expression of MACC1 and its target genes MET and FAK by quantitative PCR in 160 patients with HCC that was undergone LT.
Results: The patients with MACC1high or FAKhigh in HCCs showed a significantly shorter overall survival and higher cumulative recurrence rates after liver transplantation (LT), compared with MACC1low or FAKlow group. Multivariate analysis indicated that MACC1 alone or combination of MACC1/FAK was an independent prognostic factor for overall survival and cumulative recurrence.
Conclusions: MACC1 or combination of MACC1/FAK could serve as a novel biomarker in predicting the prognosis of HCC after LT.
Keywords: hepatocellular carcinoma, metastasis-associated in colon cancer-1, metastasis, prognosis, liver transplantation