Int J Med Sci 2023; 20(3):385-391. doi:10.7150/ijms.81214 This issue Cite

Research Paper

Liver Injury in Patients with COVID-19: A Retrospective Study

Yun Feng*, Yaping Liu*, Qian Zhao, Jiao Zhu, Xiaona Kang, Chen Mi, Peijie Li, Weizhi Li, Guifang Lu, Ai Jia, Shuixiang He, Hongxia Li

Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China
*These authors have contributed equally to this work.

Citation:
Feng Y, Liu Y, Zhao Q, Zhu J, Kang X, Mi C, Li P, Li W, Lu G, Jia A, He S, Li H. Liver Injury in Patients with COVID-19: A Retrospective Study. Int J Med Sci 2023; 20(3):385-391. doi:10.7150/ijms.81214. https://www.medsci.org/v20p0385.htm
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Abstract

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Objectives: The objective of this study is to explore the incidence, characteristics, risk factors, and prognosis of liver injury in patients with COVID-19.

Methods: We collected clinical data of 384 cases of COVID-19 and retrospectively analyzed the incidence, characteristics, and risk factors of liver injury of the patients. In addition, we followed the patient two months after discharge.

Results: A total of 23.7% of the patients with COVID-19 had liver injury, with higher serum AST (P < 0.001), ALT (P < 0.001), ALP (P = 0.004), GGT (P < 0.001), total bilirubin (P = 0.002), indirect bilirubin (P = 0.025) and direct bilirubin (P < 0.001) than the control group. The median serum AST and ALT of COVID-19 patients with liver injury were mildly elevated. Risk factors of liver injury in COVID-19 patients were age (P = 0.001), history of liver diseases (P = 0.002), alcoholic abuse (P = 0.036), body mass index (P = 0.037), severity of COVID-19 (P < 0.001), C-reactive protein (P < 0.001), erythrocyte sedimentation rate (P < 0.001), Qing-Fei-Pai-Du-Tang treatment (P = 0.032), mechanical ventilation (P < 0.001), and ICU admission (P < 0.001). Most of the patients (92.3%) with liver injury were treated with hepatoprotective drugs. 95.6% of the patients returned to normal liver function tests at 2 months after discharge.

Conclusions: Liver injury was commen in COVID-19 patients with risk factors, most of them have mild elevations in transaminases, and conservative treatment has a good short-term prognosis.

Keywords: COVID-19, liver injury, liver function tests, Severe Acute Respiratory Syndrome Coronavirus 2, Chinese traditional medicine


Citation styles

APA
Feng, Y., Liu, Y., Zhao, Q., Zhu, J., Kang, X., Mi, C., Li, P., Li, W., Lu, G., Jia, A., He, S., Li, H. (2023). Liver Injury in Patients with COVID-19: A Retrospective Study. International Journal of Medical Sciences, 20(3), 385-391. https://doi.org/10.7150/ijms.81214.

ACS
Feng, Y.; Liu, Y.; Zhao, Q.; Zhu, J.; Kang, X.; Mi, C.; Li, P.; Li, W.; Lu, G.; Jia, A.; He, S.; Li, H. Liver Injury in Patients with COVID-19: A Retrospective Study. Int. J. Med. Sci. 2023, 20 (3), 385-391. DOI: 10.7150/ijms.81214.

NLM
Feng Y, Liu Y, Zhao Q, Zhu J, Kang X, Mi C, Li P, Li W, Lu G, Jia A, He S, Li H. Liver Injury in Patients with COVID-19: A Retrospective Study. Int J Med Sci 2023; 20(3):385-391. doi:10.7150/ijms.81214. https://www.medsci.org/v20p0385.htm

CSE
Feng Y, Liu Y, Zhao Q, Zhu J, Kang X, Mi C, Li P, Li W, Lu G, Jia A, He S, Li H. 2023. Liver Injury in Patients with COVID-19: A Retrospective Study. Int J Med Sci. 20(3):385-391.

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