Int J Med Sci 2022; 19(9):1408-1416. doi:10.7150/ijms.72233 This issue

Research Paper

Association between the appendicular lean mass index or handgrip strength and bone mineral density in patients undergoing peritoneal dialysis

Seok Hui Kang, A Young Kim, Jun Young Do

Division of Nephrology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Republic of Korea

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Citation:
Kang SH, Kim AY, Do JY. Association between the appendicular lean mass index or handgrip strength and bone mineral density in patients undergoing peritoneal dialysis. Int J Med Sci 2022; 19(9):1408-1416. doi:10.7150/ijms.72233. Available from https://www.medsci.org/v19p1408.htm

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Abstract

Graphic abstract

Background: Few studies have investigated the association between muscle mass and bone mineral density (BMD) in patients undergoing peritoneal dialysis (PD). We aimed to investigate the association between muscle mass or strength and BMD in patients undergoing PD.

Methods: The data of all prevalent PD cases at a tertiary medical center between September 2017 and November 2020 were collected. Among all patients, 199 patients undergoing PD were finally analyzed. Baseline measurements including handgrip strength (HGS), appendicular lean mass (ALM) index, and BMD were obtained during a peritoneal membrane equilibration test. Patients with a T-score of ≤ -2.5 were categorized into the low BMD group.

Results: The number of male patients was 113 (56.8%). Significant differences were observed in various indices, such as BMD, body composition parameters, and laboratory findings, between male and female patients. There was a stronger association between BMD and ALM index than between BMD and HGS in male patients (r = 0.432 and P < 0.001). The association between BMD and HGS was more definitive in female patients than in male patients (r = 0.357 and P = 0.001). Univariate and mutivariate linear regression and AUROC analyses showed similar trends those obtained in correlation analyses.

Conclusion: The present study demonstrated that BMD is associated with the ALM index in male patients and with HGS in female patients undergoing PD.

Keywords: Peritoneal dialysis, Muscle mass, Bone mineral density, Handgrip strength