The Association of Targeted Gut Microbiota with Body Composition in Type 2 Diabetes Mellitus

Hung, Wei-Chun; Hung, Wei-Wen; Tsai, Hui-Ju; Chang, Chen-Chia; Chiu, Yi-Wen; Hwang, Shang-Jyh; Kuo, Mei-Chuan; Chen, Szu-Chia; Dai, Chia-Yen; Tsai, Yi-Chun

doi:10.7150/ijms.51164

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Int J Med Sci 2021; 18(2):511-519. doi:10.7150/ijms.51164 This issue Cite

Research Paper

The Association of Targeted Gut Microbiota with Body Composition in Type 2 Diabetes Mellitus

Wei-Chun Hung¹, Wei-Wen Hung², Hui-Ju Tsai³, Chen-Chia Chang¹, Yi-Wen Chiu^4,5, Shang-Jyh Hwang^4,5, Mei-Chuan Kuo^4,5, Szu-Chia Chen^4,5,6,7, Chia-Yen Dai^6,8, Yi-Chun Tsai^{4,5,6,9,10✉}

1. Department of Microbiology and Immunology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
2. Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
3. Department of Family Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
4. Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
5. Faculty of Renal Care, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
6. School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
7. Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
8. Division of Hepatobiliary, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
9. Division of General Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
10. Cohort Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.

Citation:

Hung WC, Hung WW, Tsai HJ, Chang CC, Chiu YW, Hwang SJ, Kuo MC, Chen SC, Dai CY, Tsai YC. The Association of Targeted Gut Microbiota with Body Composition in Type 2 Diabetes Mellitus. Int J Med Sci 2021; 18(2):511-519. doi:10.7150/ijms.51164. https://www.medsci.org/v18p0511.htm

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Abstract

The association between body composition and gut microbiota in type 2 diabetes mellitus (DM) remains unknown. To elucidate the correlation of body composition and gut microbiota, we conducted a clinical study to enroll 179 patients with type 2 DM. Body composition of lean tissue index (LTI) and fat tissue index was measured by Body Composition Monitor. Eight pairs of 16S rRNA gene primers specific to Firmicutes, Bacteroidetes, the Clostridium leptum group, Bacteroides, Bifidobacterium, Akkermansia muciniphila, Escherichia coli, and Faecalibacterium prausnitzii were used to measure their abundance by quantitative polymerase chain reaction. The results showed that type 2 DM with higher abundance of phylum Firmicutes and a higher ratio of phyla Firmicutes to Bacteroidetes (phyla F/B ratio) had higher LTI. This significant correlation between phyla F/B ratio and LTI was especially evident in type 2 DM with high body mass index, and independent of glycemic control or dipeptidyl peptidase-4 inhibitor usage. In conclusion, our study demonstrated the positive association of LTI with the abundance of phylum Firmicutes and the phyla F/B ratio in type 2 DM.

Keywords: Type 2 diabetes mellitus, gut microbiota, lean tissue index, Firmicutes, Bacteroidetes

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APA

Hung, W.C., Hung, W.W., Tsai, H.J., Chang, C.C., Chiu, Y.W., Hwang, S.J., Kuo, M.C., Chen, S.C., Dai, C.Y., Tsai, Y.C. (2021). The Association of Targeted Gut Microbiota with Body Composition in Type 2 Diabetes Mellitus. International Journal of Medical Sciences, 18(2), 511-519. https://doi.org/10.7150/ijms.51164.

ACS

Hung, W.C.; Hung, W.W.; Tsai, H.J.; Chang, C.C.; Chiu, Y.W.; Hwang, S.J.; Kuo, M.C.; Chen, S.C.; Dai, C.Y.; Tsai, Y.C. The Association of Targeted Gut Microbiota with Body Composition in Type 2 Diabetes Mellitus. Int. J. Med. Sci. 2021, 18 (2), 511-519. DOI: 10.7150/ijms.51164.

NLM

CSE

Hung WC, Hung WW, Tsai HJ, Chang CC, Chiu YW, Hwang SJ, Kuo MC, Chen SC, Dai CY, Tsai YC. 2021. The Association of Targeted Gut Microbiota with Body Composition in Type 2 Diabetes Mellitus. Int J Med Sci. 18(2):511-519.

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