Int J Med Sci 2020; 17(16):2531-2543. doi:10.7150/ijms.46812 This issue Cite

Research Paper

Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population

Haozhen Ma1,2, Jianmao Zheng1,2✉, Xiaolan Li1,2✉

1. Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, 510055 Guangzhou/PR. China.
2. Guanghua School of Stomatology, Sun Yat-sen University, 510055 Guangzhou/PR. China.

Citation:
Ma H, Zheng J, Li X. Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population. Int J Med Sci 2020; 17(16):2531-2543. doi:10.7150/ijms.46812. https://www.medsci.org/v17p2531.htm
Other styles

File import instruction

Abstract

Background: Some studies have reported biological linkages between periodontitis and esophageal cancer, prostate cancer, kidney cancer, hematological malignancy, and melanoma of the skin. This meta-analysis aimed to assess the relationship between periodontitis and the aforementioned five cancers.

Methods: Eligible studies on the association between periodontitis and the aforementioned five kinds of cancers were retrieved. The statistical analysis was conducted using Stata 12.0.

Results: Ten articles (more than 100,000 samples for most cancers) were included. With statistical significance, participants with periodontitis might have enhanced risks of esophageal cancer (HR = 1.79, 95% CI: 1.15-2.79), prostate cancer (HR = 1.20, 95% CI: 1.09-1.31), hematological malignancy (HR = 1.19, 95% CI: 1.09-1.29), and melanoma of skin (HR = 1.21, 95% CI: 1.03-1.42), compared with those without periodontitis. However, the evidence regarding the correlation between periodontitis and the susceptibility to kidney cancer was lacking (HR=1.30, 95% CI: 0.96-1.76).

Conclusions: The present meta-analysis revealed a potential link between periodontitis and esophageal cancer, prostate cancer, hematological malignancy, and melanoma of the skin. However, multi-center studies with large sample sizes and multivariable adjustments are still needed to support the conclusion.

Keywords: Esophageal cancer, prostate cancer, hematological malignancy, melanoma of the skin, periodontitis, meta-analysis


Citation styles

APA
Ma, H., Zheng, J., Li, X. (2020). Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population. International Journal of Medical Sciences, 17(16), 2531-2543. https://doi.org/10.7150/ijms.46812.

ACS
Ma, H.; Zheng, J.; Li, X. Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population. Int. J. Med. Sci. 2020, 17 (16), 2531-2543. DOI: 10.7150/ijms.46812.

NLM
Ma H, Zheng J, Li X. Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population. Int J Med Sci 2020; 17(16):2531-2543. doi:10.7150/ijms.46812. https://www.medsci.org/v17p2531.htm

CSE
Ma H, Zheng J, Li X. 2020. Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population. Int J Med Sci. 17(16):2531-2543.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.