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Volume 22 (8); 2025

Research Papers

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Indoxyl sulfate is associated with cognitive impairment in ESRD patients by activating the extrinsic apoptosis in the neuronal cells during differentiating process Chih-Chuan Hsieh, Kuo-Cheng Lu, Chuen-Lin Huang, Jiun-Jie Wang, Ting-Yin Yeh, Shyh-Min Lin, Ya-Ling Chung, Yi-Chou Hou, Yuahn-Sieh Huang Int. J. Med. Sci. 2025; 22(8): 1736-1749. doi:10.7150/ijms.109245 Full text PDF PubMed PMC

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Exploring the Relationship Between Gut Microbiota and Aortic Stenosis: Role of Inflammatory Proteins, Blood Metabolites, and Immune Cells Fanhui Jing, Jiapeng Zhou, Fengwen Zhang, Guangzhi Zhao, Fang Fang, Xiangbin Pan Int. J. Med. Sci. 2025; 22(8): 1750-1761. doi:10.7150/ijms.110392 Full text PDF PubMed PMC

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Assessing the Role of Polyamine Metabolites in Blood and the DNA Methylation of Mycobacterium Tuberculosis in Patients with Multidrug-Resistant Tuberculosis Li Yan, Xinxin Niu, Kuidi Liang, Feifeng Guan, Xiaolin Yu, Ziyu Ye, Mingyuan Huang, Hancheng Liang, Xinguang Zhong, Jincheng Zeng Int. J. Med. Sci. 2025; 22(8): 1762-1772. doi:10.7150/ijms.102568 Full text PDF PubMed PMC

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Integrated Phenotypic and Transcriptomic Analyses of Osteoporosis in Type 2 Diabetic Mice Shu-Juan Xing, Ying-Feng Gao, Lu Liu, Bing-Dong Sui, Ning-Ning Da, Jin-Yu Liu, Hao Wang, Yuan Yuan, Yuan Qin, Pei-Sheng Liu, Si-Qi Ying, Kai Zhang, Jie-Xi Liu, Ji Chen, Yi-Han Liu, Xin Xie, Yan Jin, Sha Zhang, Chen-Xi Zheng Int. J. Med. Sci. 2025; 22(8): 1773-1790. doi:10.7150/ijms.109537 Full text PDF PubMed PMC

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Mechanisms of Huhuang decoction in treating diabetic wounds: a network pharmacological and experimental study Jie Zhang, Yan Shi, Jiaqiang Wang, Min Gao, Shan Zhong, Yunsheng Chen, Jiaqi Hao, Peilang Yang, Shun Xu, Yan Liu Int. J. Med. Sci. 2025; 22(8): 1811-1824. doi:10.7150/ijms.108187 Full text PDF PubMed PMC

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Oncogenic and Immunological Roles of FRS2 and its Potential Value in Retroperitoneal Liposarcoma: from Bioinformatics Analysis to Clinicopathological Evidence Hao Yu, Shuquan Li, Yifan Wu, Zhen Wang, Xiaopeng Wang, Sha Zhang, Xiaoya Guan, Bin Dong, Chunyi Hao, Xiuyun Tian, Ang Lv Int. J. Med. Sci. 2025; 22(8): 1825-1836. doi:10.7150/ijms.103802 Full text PDF PubMed PMC

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Bioprospection of Hura crepitans metabolites against oxidative stress and inflammation: An in vitro and in silico exploration Yu-Cheng Kuo, Bashir Lawal, Halimat Yusuf Lukman, Lung-Ching Chen, Sheng-Liang Huang, Yi-Fong Chen, Adewale O. Fadaka, Femi Olawale, Ayo Olasupo, Olabode T Ajenifujah, Dalia Fouad, Marios Papadakis, Gaber El-Saber Batiha, Saheed Sabiu, Alexander T.H. Wu, Hsu-Shan Huang Int. J. Med. Sci. 2025; 22(8): 1837-1851. doi:10.7150/ijms.109116 Full text PDF PubMed PMC

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Mitochondrial Quality Control Systems in Septic AKI: Molecular Mechanisms and Therapeutic Implications Ying Tan, Yue Ouyang, Zisheng Ma, Jianming Huang, Chuhong Tan, Junxiong Qiu, Feng Wu Int. J. Med. Sci. 2025; 22(8): 1852-1864. doi:10.7150/ijms.107012 Full text PDF PubMed PMC

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Danshensu Attenuates Palmitic Acid-Induced Activation of Hepatic Stellate Cells by Regulating Pyroptosis Han-Fang Tseng, Huan-Nung Chao, Chih-Hung Lin, Chan-Yen Kuo Int. J. Med. Sci. 2025; 22(8): 1865-1874. doi:10.7150/ijms.107564 Full text PDF PubMed PMC

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Gene Signature-Based Prognostic Model for Acute Myeloid Leukemia: The Role of BATF, EGR1, PD-1, PD-L1, and TIM-3 Yupei Zhang, Zhixi Chen, Jiamian Zheng, Shaohua Chen, Liye Zhong, Jie Chen, Cunte Chen, Songnan Sui, Yangqiu Li Int. J. Med. Sci. 2025; 22(8): 1875-1884. doi:10.7150/ijms.108527 Full text PDF PubMed PMC

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In Silico Identification of ANKRD22 as a Theragnostic Target for Pancreatic Cancer and Fostamatinib's Therapeutic Potential Huong Thi Luu Kim Huynh, Hendrick Gao-Min Lim, Yuan-Chii Gladys Lee, Thien-Vy Phan, Thanh-Hoa Vo, Chien-Hsin Chen, Alexander T.H. Wu Int. J. Med. Sci. 2025; 22(8): 1885-1904. doi:10.7150/ijms.105193 Full text PDF PubMed PMC

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MUC15 acts as a tumor suppressor gene which correlates with prognosis and immune infiltration in esophageal squamous cell carcinoma Xiang Fei, Ai-li Wang, Hao Wu, Si-wei Xing, Lei Chen, Ying Chen, Xue-jing Lin, Hai-long Liu, Bin Sun Int. J. Med. Sci. 2025; 22(8): 1905-1915. doi:10.7150/ijms.108926 Full text PDF PubMed PMC

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Predictors of the Fear of COVID-19 in Individuals with Schizophrenia: a Prospective Study Cheng-Fang Yen, Ching-Shu Tsai, Chien-Wen Lin, Ray C. Hsiao, Peng-Wei Wang Int. J. Med. Sci. 2025; 22(8): 1916-1923. doi:10.7150/ijms.106953 Full text PDF PubMed PMC

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Hematological parameters and major adverse cardiovascular events: a prospective study in a Chinese population involving 2,970 participants Hongna Mu, Xinyue Wang, Xianghui Zhao, Ruiyue Yang, Wenduo Zhang, Hongxia Li, Siming Wang, Fusui Ji, Wenxiang Chen, Jun Dong, Xue Yu Int. J. Med. Sci. 2025; 22(8): 1924-1935. doi:10.7150/ijms.104118 Full text PDF PubMed PMC

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FBXW2 inhibits the progression of gastric cancer via promoting β-catenin ubiquitylation Yanshen Kuang, Mu Ke, Weizheng Liu, Fengming Xu Int. J. Med. Sci. 2025; 22(8): 1936-1943. doi:10.7150/ijms.108501 Full text PDF PubMed PMC

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How telomere maintenance affects endometriosis development: a preliminary study Xiaoling Zhao, Weimin Kong, Dan Luo, Yunkai Xie, He Zhang Int. J. Med. Sci. 2025; 22(8): 1944-1957. doi:10.7150/ijms.102646 Full text PDF PubMed PMC

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Integrating Single-Cell and Bulk RNA Sequencing Data to Explore Sphingolipid Metabolism Molecular Signatures in Ovarian Cancer Prognosis: an Original Study Xu Huang, Xiaoyu Li, Wulin Shan, Yingyu Dou, Qiongli Yu, Yao Chen, Zengying Wang, Haomin Zhang, Yumeng Wang, Xiaofei Lu, Wenju Peng, Bairong Xia Int. J. Med. Sci. 2025; 22(8): 1958-1977. doi:10.7150/ijms.107391 Full text PDF PubMed PMC

Reviews

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The roles of the ubiquitin-proteasome system in renal disease Danqin Lu, Yingying Zhang, Ping Zhu, Jiao Wu, Cheng Yuan, Lihua Ni Int. J. Med. Sci. 2025; 22(8): 1791-1810. doi:10.7150/ijms.107284 Full text PDF PubMed PMC

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RNA-binding proteins as a molecular link between COPD and pulmonary hypertension Yi Liu, Ran Wang, Tao Jiang Int. J. Med. Sci. 2025; 22(8): 1979-1991. doi:10.7150/ijms.108587 Full text PDF PubMed PMC

Erratum

Overexpression of ATAD2 indicates Poor Prognosis in Oral Squamous Cell Carcinoma: Erratum Xiao-Long Wang, Shuo Wang, Zhi-Zhong Wu, Qi-Chao Yang, Hao Li, Hong-Gang Xiong, Shu-Cheng Wan, Zhi-Jun Sun Int. J. Med. Sci. 2025; 22(8): 1978. doi:10.7150/ijms.112159 Full text PDF PubMed PMC

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