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Int J Med Sci 2024; 21(2):369-375. doi:10.7150/ijms.89370 This issue Cite

Review

NAD+-A Hub of Energy Metabolism in Heart Failure

Yaoxin Wu1, Zuowei Pei1,2✉, Peng Qu1✉

1. Faculty of Medicine, Dalian University of Technology, 116024, Dalian, China.
2. Department of Cardiology, Central Hospital of Dalian University of Technology, Dalian, 116033, China.

✉ Corresponding authors: Peng Qu, Faculty of Medicine, Dalian University of Technology, 116024, Dalian, China. Telephone number: 0411-84706670. E-mail: qupengedu.cn. Zuowei Pei, Department of Cardiology, Central Hospital of Dalian University of More

Citation:
Wu Y, Pei Z, Qu P. NAD+-A Hub of Energy Metabolism in Heart Failure. Int J Med Sci 2024; 21(2):369-375. doi:10.7150/ijms.89370. https://www.medsci.org/v21p0369.htm
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Abstract

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Heart failure is a condition where reduced levels of adenosine triphosphate (ATP) affect energy supply in myocardial cells. Nicotinamide adenine dinucleotide (NAD+) plays a crucial role as a coenzyme for electron transfer in energy metabolism. Decreased NAD+ levels in myocardial cells lead to inadequate ATP production and increased susceptibility to heart failure. Researchers are exploring ways to increase NAD+ levels to alleviate heart failure. Targets such as sirtuin2 (sirt2), sirtuin3 (sirt3), Poly (ADP-ribose) polymerase (PARP), and diastolic regulatory proteins are being investigated. NAD+ supplementation has shown promise, even in heart failure with preserved ejection fraction (HFpEF). By focusing on NAD+ as a central component of energy metabolism, it is possible to improve myocardial activity, heart function, and address energy deficiency in heart failure.

Keywords: NAD+, Energy Metabolism, Heart Failure, Mitochondria

Citation styles

APA
Wu, Y., Pei, Z., Qu, P. (2024). NAD+-A Hub of Energy Metabolism in Heart Failure. International Journal of Medical Sciences, 21(2), 369-375. https://doi.org/10.7150/ijms.89370.

ACS
Wu, Y.; Pei, Z.; Qu, P. NAD+-A Hub of Energy Metabolism in Heart Failure. Int. J. Med. Sci. 2024, 21 (2), 369-375. DOI: 10.7150/ijms.89370.

NLM
Wu Y, Pei Z, Qu P. NAD+-A Hub of Energy Metabolism in Heart Failure. Int J Med Sci 2024; 21(2):369-375. doi:10.7150/ijms.89370. https://www.medsci.org/v21p0369.htm

CSE
Wu Y, Pei Z, Qu P. 2024. NAD+-A Hub of Energy Metabolism in Heart Failure. Int J Med Sci. 21(2):369-375.

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