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Int J Med Sci 2023; 20(1):57-69. doi:10.7150/ijms.77944 This issue Cite

Research Paper

TRPM2 facilitates tumor progression of clear cell renal cell carcinoma by relieving Endoplasmic Reticulum Stress

Hongwei Yuan1#, Weiquan Li1#, Ning Lou2#, Tiexi Yu1, Xiangui Meng1✉, Wen Xiao1✉, Xiaoping Zhang1✉

1. Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
2. Department of Urology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
#Equal contribution authors.

✉ Corresponding authors: Xiaoping Zhang, Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; E-mail: xzhangedu.cn; Wen Xiao, Department of Urology, Union Hospital, T More

Citation:
Yuan H, Li W, Lou N, Yu T, Meng X, Xiao W, Zhang X. TRPM2 facilitates tumor progression of clear cell renal cell carcinoma by relieving Endoplasmic Reticulum Stress. Int J Med Sci 2023; 20(1):57-69. doi:10.7150/ijms.77944. https://www.medsci.org/v20p0057.htm
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Abstract

Graphic abstract

Clear cell renal cell carcinoma (ccRCC) has the highest incidence rate among all pathological types of kidney cancers. Although the role of transient receptor potential (TRP) ion channel TRPM2 has been studied in many cancers, its function in ccRCC is still unexplored. In this study, using the KIRC module of TCGA, we found that TRPM2 was upregulated in ccRCC tissues and was related to poor prognosis. Gene set enrichment analysis (GSEA) showed that TRPM2 was related to epithelial-to-mesenchymal transition (EMT), TCA cycle, fatty acid metabolism, and immune system-related functions. Functional experimental results indicated that TRPM2 could promote ccRCC progression. Furthermore, mechanism analysis showed that knocking out TRPM2 can reverse these phenotypes by increasing endoplasmic reticulum stress and decreasing EMT. We also investigated the potential role of TRPM2 in immune cell infiltration in the tumor microenvironment. Our study indicated that TRPM2 promotes ccRCC progression and may be a novel target for ccRCC therapy.

Keywords: TRPM2, Endoplasmic Reticulum Stress, ccRCC, Tumor progression

Citation styles

APA
Yuan, H., Li, W., Lou, N., Yu, T., Meng, X., Xiao, W., Zhang, X. (2023). TRPM2 facilitates tumor progression of clear cell renal cell carcinoma by relieving Endoplasmic Reticulum Stress. International Journal of Medical Sciences, 20(1), 57-69. https://doi.org/10.7150/ijms.77944.

ACS
Yuan, H.; Li, W.; Lou, N.; Yu, T.; Meng, X.; Xiao, W.; Zhang, X. TRPM2 facilitates tumor progression of clear cell renal cell carcinoma by relieving Endoplasmic Reticulum Stress. Int. J. Med. Sci. 2023, 20 (1), 57-69. DOI: 10.7150/ijms.77944.

NLM
Yuan H, Li W, Lou N, Yu T, Meng X, Xiao W, Zhang X. TRPM2 facilitates tumor progression of clear cell renal cell carcinoma by relieving Endoplasmic Reticulum Stress. Int J Med Sci 2023; 20(1):57-69. doi:10.7150/ijms.77944. https://www.medsci.org/v20p0057.htm

CSE
Yuan H, Li W, Lou N, Yu T, Meng X, Xiao W, Zhang X. 2023. TRPM2 facilitates tumor progression of clear cell renal cell carcinoma by relieving Endoplasmic Reticulum Stress. Int J Med Sci. 20(1):57-69.

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