Int J Med Sci 2022; 19(1):82-88. doi:10.7150/ijms.66876 This issue

Research Paper

Association of plasma fatty acid-binding protein 3 with estimated glomerular filtration rate in patients with type 2 diabetes mellitus

Teng-Hung Yu1,5*, Chin-Feng Hsuan1,5,11*, Cheng-Ching Wu1,5, Wei-Chin Hung1,5, Thung-Lip Lee1,6, I-Ting Tsai2,5, Ching-Ting Wei3,6,7,8, Jer-Yiing Houng9,10, Fu-Mei Chung1, Yau-Jiunn Lee12, Yung-Chuan Lu4,6✉

1. Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445 Taiwan.
2. Department of Emergency, E-Da Hospital, Kaohsiung 82445 Taiwan.
3. Division of General Surgery, Department of Surgery, E-Da Hospital, Kaohsiung 82445 Taiwan.
4. Division of Endocrinology and Metabolism, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445 Taiwan.
5. School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan.
6. School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan.
7. Department of Biomedical Engineering, I-Shou University, Kaohsiung, 82445 Taiwan.
8. Department of Electrical Engineering, I-Shou University, Kaohsiung, 82445 Taiwan.
9. Department of Nutrition, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan.
10. Department of Chemical Engineering, I-Shou University, Kaohsiung, 82445 Taiwan.
11. Division of Cardiology, Department of Internal Medicine, E-Da Dachang Hospital, Kaohsiung, 80794 Taiwan.
12. Lee's Endocrinologic Clinic, Pingtung 90000 Taiwan.
*These authors contributed equally to this work.

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Citation:
Yu TH, Hsuan CF, Wu CC, Hung WC, Lee TL, Tsai IT, Wei CT, Houng JY, Chung FM, Lee YJ, Lu YC. Association of plasma fatty acid-binding protein 3 with estimated glomerular filtration rate in patients with type 2 diabetes mellitus. Int J Med Sci 2022; 19(1):82-88. doi:10.7150/ijms.66876. Available from https://www.medsci.org/v19p0082.htm

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Abstract

Graphic abstract

Background: Fatty acid-binding protein 3 (FABP3) located in renal mesangial and distal tubular cells, and had been shown to be a sensitive marker of renal injury, potentially be a mediator in pathogenesis of chronic kidney disease (CKD). Our previous study revealed that plasma FABP1 and FABP2 were independently associated with CKD, however, little is known about the relationship between plasma FABP3 level and CKD. The aim of this study was therefore to evaluate the plasma levels of FABP3 at different stages of estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 334 subjects with T2DM who enrolled in a disease management program were included in this study and stratified according to eGFR. Plasma FABP3 concentrations were measured by an enzyme-linked immunosorbent assay.

Results: FABP3 levels increased in parallel with the eGFR level. Increasing concentrations of FABP3 were independently and significantly associated with eGFR stage G2-G4. Age- and sex-adjusted FABP3 levels were positively associated with uric acid, urinary albumin-to-creatinine ratio, FABP1, FABP2, and fatty liver index, but negatively associated with eGFR and hemoglobin.

Conclusion: Our results indicate that circulating FABP3 in patients with T2DM is associated with eGFR, which suggests that increased plasma FABP3 may be involved in the pathogenesis of CKD.

Keywords: Type 2 diabetes mellitus, fatty acid-binding protein 3, estimated glomerular filtration rate