Int J Med Sci 2022; 19(1):25-33. doi:10.7150/ijms.58428 This issue

Review

Changes of Migration, Immunoregulation and Osteogenic Differentiation of Mesenchymal Stem Cells in Different Stages of Inflammation

Feng Gu, Ke Zhang, Jiangbi Li, Xiaoping Xie, Qiangqiang Wen, Zhenjiang Sui, Zilong Su, Tiecheng Yu

Department of Orthopedics, First Hospital of Jilin University, Changchun 130021, Jilin, China.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Citation:
Gu F, Zhang K, Li J, Xie X, Wen Q, Sui Z, Su Z, Yu T. Changes of Migration, Immunoregulation and Osteogenic Differentiation of Mesenchymal Stem Cells in Different Stages of Inflammation. Int J Med Sci 2022; 19(1):25-33. doi:10.7150/ijms.58428. Available from https://www.medsci.org/v19p0025.htm

File import instruction

Abstract

Graphic abstract

Bone infection has always been the focus of orthopedic research. Mesenchymal stem cells (MSCs) are the natural progenitors of osteoblasts, and the process of osteogenesis is triggered in response to different signals from the extracellular matrix. MSCs exert important functions including secretion and immune regulation and also play a key role in bone regeneration. The biological behavior of MSCs in acute and chronic inflammation, especially the transformation between acute inflammation and chronic inflammation, has aroused great interest among researchers. This paper reviews the recent literature and summarizes the behavior and biological characteristics of MSCs in acute and chronic inflammation to stimulate further research on MSCs and treatment of bone diseases.

Keywords: Mesenchymal Stem Cells, Infection, Immunomodulatory, Differentiation