Int J Med Sci
2021; 18(16):3794-3799.
doi:10.7150/ijms.61973 This issueCite
Review
Role of interferon regulatory factor-mediated signaling in psoriasis
Wen-Ming Wang, Feng Li, Hong-Zhong Jin✉
Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
✉ Corresponding author: Hong-Zhong Jin, M.D. Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1, Shuaifuyuan Wangfujing Dongcheng District, Beijing 100730, China. Telephone& Fax: +86 010 69151502; E-mail: jinhongzhongnet.More
Citation:
Wang WM, Li F, Jin HZ. Role of interferon regulatory factor-mediated signaling in psoriasis. Int J Med Sci 2021; 18(16):3794-3799. doi:10.7150/ijms.61973. https://www.medsci.org/v18p3794.htm
Psoriasis is a chronic inflammatory disease that involves both the innate and adaptive immune systems. Type I interferons (IFNs), the production of which is partially regulated by toll-like receptors (TLRs), play an important role in the pathogenesis of psoriasis, especially psoriasis caused by skin trauma, known as the Koebner phenomenon. IFN regulatory factors (IRFs) function in both innate and adaptive immune responses, and their effect is associated with the regulation of type I IFNs. In this review, we focus on recent advances in understanding the expression of TLRs, IRFs, and type I IFNs in psoriasis. We also highlight the interplay among TLRs, IRFs, and type I IFNs.
Keywords: Psoriasis, Type I Interferons, Toll-Like Receptors, Interferon Regulatory Factors
Citation styles
APA
Wang, W.M., Li, F., Jin, H.Z. (2021). Role of interferon regulatory factor-mediated signaling in psoriasis. International Journal of Medical Sciences, 18(16), 3794-3799. https://doi.org/10.7150/ijms.61973.
ACS
Wang, W.M.; Li, F.; Jin, H.Z. Role of interferon regulatory factor-mediated signaling in psoriasis. Int. J. Med. Sci. 2021, 18 (16), 3794-3799. DOI: 10.7150/ijms.61973.
NLM
Wang WM, Li F, Jin HZ. Role of interferon regulatory factor-mediated signaling in psoriasis. Int J Med Sci 2021; 18(16):3794-3799. doi:10.7150/ijms.61973. https://www.medsci.org/v18p3794.htm
CSE
Wang WM, Li F, Jin HZ. 2021. Role of interferon regulatory factor-mediated signaling in psoriasis. Int J Med Sci. 18(16):3794-3799.
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