Int J Med Sci 2021; 18(16):3794-3799. doi:10.7150/ijms.61973 This issue

Review

Role of interferon regulatory factor-mediated signaling in psoriasis

Wen-Ming Wang, Feng Li, Hong-Zhong Jin

Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

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Citation:
Wang WM, Li F, Jin HZ. Role of interferon regulatory factor-mediated signaling in psoriasis. Int J Med Sci 2021; 18(16):3794-3799. doi:10.7150/ijms.61973. Available from https://www.medsci.org/v18p3794.htm

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Abstract

Graphic abstract

Psoriasis is a chronic inflammatory disease that involves both the innate and adaptive immune systems. Type I interferons (IFNs), the production of which is partially regulated by toll-like receptors (TLRs), play an important role in the pathogenesis of psoriasis, especially psoriasis caused by skin trauma, known as the Koebner phenomenon. IFN regulatory factors (IRFs) function in both innate and adaptive immune responses, and their effect is associated with the regulation of type I IFNs. In this review, we focus on recent advances in understanding the expression of TLRs, IRFs, and type I IFNs in psoriasis. We also highlight the interplay among TLRs, IRFs, and type I IFNs.

Keywords: Psoriasis, Type I Interferons, Toll-Like Receptors, Interferon Regulatory Factors