Int J Med Sci 2021; 18(6):1502-1509. doi:10.7150/ijms.54423 This issue

Review

The Effect of Immunosuppressive Drugs on MMPs Activity in The Walls of Blood Vessels - A Systematic Review

Anna Surówka1, Aleksandra Wilk2✉, Kamila Szumilas3, Karolina Kędzierska-Kapuza1,4

1. Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland.
2. Department of Histology and Embryology, Pomeranian Medical University, 70-111 Szczecin, Poland.
3. Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
4. Clinical Department of Gastroenterological Surgery and Transplantation, Central Clinical Hospital of the MSWiA in Warsaw, Poland.

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Citation:
Surówka A, Wilk A, Szumilas K, Kędzierska-Kapuza K. The Effect of Immunosuppressive Drugs on MMPs Activity in The Walls of Blood Vessels - A Systematic Review. Int J Med Sci 2021; 18(6):1502-1509. doi:10.7150/ijms.54423. Available from https://www.medsci.org/v18p1502.htm

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Abstract

Graphic abstract

The current study focuses on the role of MMPs in the pathogenesis of the vascular damage and at the same time it offers the review referring to the influence of the immunosuppressive treatment on this interdependence. Contemporary immunosuppressive treatment constitutes of four groups of medications, such as: calcineurin inhibitors including cyclosporine A and tacrolimus; inhibitors of the inosine monophosphate dehydrogenase - the only agent from this group currently used in transplantation is mycophenalate mofetil (MMF); mTOR inhibitors, consisting of everolimus and glucocorticosteroids. Due to the fact that the properties of immunosuppressive drugs still remain unclear and transplant recipients need to use these medicines every day, knowledge of this should be further expanded. The deceases of the patients with the functioning graft who were diagnosed with the cardiovascular system diseases, constitute 50% of all renal transplant recipients. Immunosuppressive treatment leads to many pathological alterations within the organs and tissues and additionally they undoubtedly affect the activity of MMPs in the wall of the vessels.

Keywords: immunosuppressive drugs, metalloproteinases, inhibitors, extracellular matrix.