Int J Med Sci 2021; 18(4):964-974. doi:10.7150/ijms.49460 This issue

Research Paper

STAT3/miR-15a-5p/CX3CL1 Loop Regulates Proliferation and Migration of Vascular Endothelial Cells in Atherosclerosis

Hui Li1#, Hui-Min Zhang2#, Li-Juan Fan3#, Han-Han Li2, Zi-Tan Peng4, Jia-Peng Li2, Xiao-Yu Zhang2, Yuan Xiang2, Chao-Jiang Gu2, Xing-Hua Liao2✉, Li Wang5✉, Tong-Cun Zhang2,6✉

1. College of Life Sciences and Health, School of Resource and Environmental Engineering, Wuhan University of Science and Technology, Hubei, 430081, P.R.China.
2. College of Life Sciences and Health, Wuhan University of Science and Technology, Hubei, 430081, P.R.China.
3. Tianyou Hospital Affiliated To Wuhan University of Science and Technology, Hubei, 430000, P.R.China.
4. Huangshi Central Hospital, Hubei, 435000, P.R.China.
5. School of Resource and Environmental Engineering, Wuhan University of Science and Technology, Hubei, 430081, P.R.China.
6. Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education and Tianjin, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, P.R.China.
#These authors contributed equally to this work.

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Citation:
Li H, Zhang HM, Fan LJ, Li HH, Peng ZT, Li JP, Zhang XY, Xiang Y, Gu CJ, Liao XH, Wang L, Zhang TC. STAT3/miR-15a-5p/CX3CL1 Loop Regulates Proliferation and Migration of Vascular Endothelial Cells in Atherosclerosis. Int J Med Sci 2021; 18(4):964-974. doi:10.7150/ijms.49460. Available from https://www.medsci.org/v18p0964.htm

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Abstract

Endothelial cell proliferation disorder caused by vascular injury seems to be one of the causes of atherosclerosis, which is the pathological basis of coronary heart disease. The role of STAT3 in the regulation of microRNAs and endothelial dysfunction in atherosclerosis is unclear. STAT3 can be activated by cytokine IL-6 and up regulate the expression of CX3CL1. In addition, microRNA-15a-5p (miR-15a-5p) inhibited the transcription of CX3CL1, the proliferation of vascular endothelial cells and the proliferation of STAT3 regulated vascular endothelial cells. STAT3 positively regulates the expression of CX3CL1, and then down-regulates the inhibition of CX3CL1 by over-expression of miR-15a-5p, thus forming an elimination feedback loop to control the proliferation of HUVECs and affect the progression of atherosclerosis. In conclusion, miR-15a-5p may be the therapeutic target of the pathological basis of coronary atherosclerosis.

Keywords: STAT3, MicroRNA-15a, CX3CL1, Endothelial cells, Atherosclerosis