Int J Med Sci 2015; 12(12):968-973. doi:10.7150/ijms.13121 This issue Cite

Research Paper

QT interval Independently Predicts Mortality and Heart Failure in Patients with ST-Elevation Myocardial Infarction

Jeng-Feng Lin1,2, Shun-Yi Hsu1,2, Semon Wu1,3, Ming-Sheng Teng1, Hsin-Hua Chou1, Shih-Tsung Cheng1, Tien-Yu Wu1, Yu-Lin Ko1,2 ✉

1. Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan;
2. School of Medicine, Tzu Chi University, Hualien, Taiwan;
3. Department of Life Science, Chinese Culture University, Taipei, Taiwan.

Citation:
Lin JF, Hsu SY, Wu S, Teng MS, Chou HH, Cheng ST, Wu TY, Ko YL. QT interval Independently Predicts Mortality and Heart Failure in Patients with ST-Elevation Myocardial Infarction. Int J Med Sci 2015; 12(12):968-973. doi:10.7150/ijms.13121. https://www.medsci.org/v12p0968.htm
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Abstract

Objectives: Heart-rate corrected QT (QTc) interval predicts cardiovascular mortality or all-cause mortality in the general population. Little is known about the best cut-off value of QTc interval for predicting clinical events in patients with ST-elevation myocardial infarction (STEMI).

Methods: We enrolled 264 patients with STEMI who received measurement of QTc intervals at ER (QTc-ER), on day 2 (QTc-D2), and on day 3 (QTc-D3) of hospitalization. Clinical events, including all-cause death and readmission for heart failure, were followed for 2 years.

Results: Prolonged QTc-ER, but not QTc-D2 or QTc-D3, well predicted clinical events with the best cut-off value of 445 ms. Patient with QTc-ER > 445 ms had lower left ventricular ejection fraction at baseline and at 6 months. Kaplan-Meier survival curves showed that the combination of QTc-ER > 445 ms and N-terminal pro-brain natriuretic peptide (NT-pro BNP) > 936 pg/mL was a strong predictor of clinical events (p<0.001). In multivariable Cox regression analysis, the independent predictors of death and heart failure were QTc-ER (p<0.001), log NT-proBNP (p<0.001), diabetes mellitus (p<0.001), history of stroke (p=0.001), and left ventricular end diastolic volume index (p<0.001).

Conclusion: QTc-ER > 445 ms independently predicts clinical events in STEMI, providing incremental prognostic value to established clinical predictors and NT-proBNP.

Keywords: QT interval, brain natriuretic peptide, acute myocardial infarction, left ventricular remodeling.


Citation styles

APA
Lin, J.F., Hsu, S.Y., Wu, S., Teng, M.S., Chou, H.H., Cheng, S.T., Wu, T.Y., Ko, Y.L. (2015). QT interval Independently Predicts Mortality and Heart Failure in Patients with ST-Elevation Myocardial Infarction. International Journal of Medical Sciences, 12(12), 968-973. https://doi.org/10.7150/ijms.13121.

ACS
Lin, J.F.; Hsu, S.Y.; Wu, S.; Teng, M.S.; Chou, H.H.; Cheng, S.T.; Wu, T.Y.; Ko, Y.L. QT interval Independently Predicts Mortality and Heart Failure in Patients with ST-Elevation Myocardial Infarction. Int. J. Med. Sci. 2015, 12 (12), 968-973. DOI: 10.7150/ijms.13121.

NLM
Lin JF, Hsu SY, Wu S, Teng MS, Chou HH, Cheng ST, Wu TY, Ko YL. QT interval Independently Predicts Mortality and Heart Failure in Patients with ST-Elevation Myocardial Infarction. Int J Med Sci 2015; 12(12):968-973. doi:10.7150/ijms.13121. https://www.medsci.org/v12p0968.htm

CSE
Lin JF, Hsu SY, Wu S, Teng MS, Chou HH, Cheng ST, Wu TY, Ko YL. 2015. QT interval Independently Predicts Mortality and Heart Failure in Patients with ST-Elevation Myocardial Infarction. Int J Med Sci. 12(12):968-973.

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