ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia Proliferation Via the NF-κB Signaling Pathway

Shao, Xin; Zhong, Liang; Chu, Xuan; Wan, Peng; Chen, Shuyu; Zhou, Ziwei; Zhang, Hongyan; Wang, Meng; Liu, Beizhong

doi:10.7150/ijms.80047

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Int J Med Sci 2023; 20(4):520-529. doi:10.7150/ijms.80047 This issue Cite

Research Paper

ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia Proliferation Via the NF-κB Signaling Pathway

Xin Shao¹, Liang Zhong², Xuan Chu¹, Peng Wan¹, Shuyu Chen¹, Ziwei Zhou¹, Hongyan Zhang¹, Meng Wang¹, Beizhong Liu^1,2,✉

1. Central Laboratory of Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China
2. Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China

Citation:

Shao X, Zhong L, Chu X, Wan P, Chen S, Zhou Z, Zhang H, Wang M, Liu B. ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia Proliferation Via the NF-κB Signaling Pathway. Int J Med Sci 2023; 20(4):520-529. doi:10.7150/ijms.80047. https://www.medsci.org/v20p0520.htm

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Abstract

Acute myeloid leukemia (AML) is a malignancy of the hematological system, for which there remains an urgent need for new therapeutic and diagnostic targets. COMM domain containing 7 (COMMD7) is a recently-identified oncogene linked to poor prognosis in AML. COMMD7 regulates multiple signaling pathways, including nuclear factor-kappa B (NF-κB) signaling. Here, we report that COMMD7 is highly expressed in the AML cell lines KG1a and U937 and that its inhibition by shRNA reduced proliferation, promoted apoptosis and facilitated cell cycle arrest in the G2/M phase in relation to depression of the NF-κB pathway. Furthermore, zinc finger protein 460 (ZNF460) is overexpressed in AML and regulates COMMD7. We found that knockdown of ZNF460 downregulated the expression of COMMD7 while the NF-κB pathway was also inhibited. In addition, we noticed that knockdown of ZNF460 reduced proliferation and increased apoptosis rate of AML cells and that the cell cycle was blocked in the G2/M phase. In brief, our results revealed a critical effect of the ZNF460-COMMD7-NF-κB axis for the proliferation of AML cells. Therefore, COMMD7 may be a possible therapeutic target for AML.

Keywords: Acute myeloid leukemia, COMMD7, ZNF460, NF-κB pathway, Proliferation

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APA

Shao, X., Zhong, L., Chu, X., Wan, P., Chen, S., Zhou, Z., Zhang, H., Wang, M., Liu, B. (2023). ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia Proliferation Via the NF-κB Signaling Pathway. International Journal of Medical Sciences, 20(4), 520-529. https://doi.org/10.7150/ijms.80047.

ACS

Shao, X.; Zhong, L.; Chu, X.; Wan, P.; Chen, S.; Zhou, Z.; Zhang, H.; Wang, M.; Liu, B. ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia Proliferation Via the NF-κB Signaling Pathway. Int. J. Med. Sci. 2023, 20 (4), 520-529. DOI: 10.7150/ijms.80047.

NLM

CSE

Shao X, Zhong L, Chu X, Wan P, Chen S, Zhou Z, Zhang H, Wang M, Liu B. 2023. ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia Proliferation Via the NF-κB Signaling Pathway. Int J Med Sci. 20(4):520-529.

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