Int J Med Sci 2021; 18(2):520-527. doi:10.7150/ijms.50705 This issue Cite

Research Paper

The role of chest CT in management of asymptomatic SARS-CoV-2 infections: A longitudinal multi-center study in Chongqing, China

Ting Chen1, Dajing Guo1, Jianguo Lu2, Bo Xiang3, Xiang Li4, Jianghua Nie5, Xiaojing He1, Kunhua Li1✉

1. Department of Radiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
2. Department of Radiology, the Second Affiliated Hospital of Chongqing Medical University at Fengjie, Chongqing, China.
3. Department of Radiology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
4. Department of Radiology, Chongqing Three Gorges Central Hospital, Chongqing, China.
5. Department of Radiology, People's Hospital of Changshou Chongqing, Chongqing, China.

Citation:
Chen T, Guo D, Lu J, Xiang B, Li X, Nie J, He X, Li K. The role of chest CT in management of asymptomatic SARS-CoV-2 infections: A longitudinal multi-center study in Chongqing, China. Int J Med Sci 2021; 18(2):520-527. doi:10.7150/ijms.50705. https://www.medsci.org/v18p0520.htm
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Abstract

Background: Multiple societies including the Fleischner Society do not recommend that CT is routinely used in asymptomatic SARS-CoV-2 infections; however, this advice is based on the limited evidence. In this study, we aim to confirm whether it is necessary to do CT scans in SARS-CoV-2 asymptomatic infections by summarizing the longitudinal chest CT and clinical features of asymptomatic SARS-CoV-2 infections.

Methods: A total of 33 individuals (14 men and 19 women) with asymptomatic SARS-CoV-2 infections were retrospectively enrolled. Clinical data of CT positive and negative groups were compared. Longitudinal chest CT scans were reviewed for CT features and analyzed for temporal change.

Results: Thirty-two (97%) individuals had positive results for first RT-PCR testing. For clinical data, only monocyte count showed a significant difference between CT positive and negative groups. For first chest CT, only eighteen (54.5%) individuals had abnormal manifestations, common CT features were GGO (88.9%) and consolidation (33.3%), the median number of segments involved was 3.0 (1.0-7.5). No case in CT negative group was abnormal on the follow-up CT. Three patterns of evolution throughout series of CT were observed in CT positive group, including gradual improvement (12, 66.7%), mismatch to improvement (3, 16.7%) and mild progression to improvement (3, 16.7%). On last CT scans, most cases had radiographic improvement but residual abnormalities. Significant differences were exhibited in density, long diameter, number of lung segments involved, and percentage of consolidation between the first and last CT scans. All cases had stable conditions and finally confirmed negative for SARS-CoV-2 RT-PCR tests without developing into severe pneumonia.

Conclusion: Considering poor performance of CT in screening, stable conditions during followup, and good outcomes in asymptomatic SARS-CoV-2 infections, we confirm that it is unnecessary to do CT scans in asymptomatic SARS-CoV-2 infections.

Keywords: SARS-CoV-2, COVID-19, Asymptomatic infections, Chest CT


Citation styles

APA
Chen, T., Guo, D., Lu, J., Xiang, B., Li, X., Nie, J., He, X., Li, K. (2021). The role of chest CT in management of asymptomatic SARS-CoV-2 infections: A longitudinal multi-center study in Chongqing, China. International Journal of Medical Sciences, 18(2), 520-527. https://doi.org/10.7150/ijms.50705.

ACS
Chen, T.; Guo, D.; Lu, J.; Xiang, B.; Li, X.; Nie, J.; He, X.; Li, K. The role of chest CT in management of asymptomatic SARS-CoV-2 infections: A longitudinal multi-center study in Chongqing, China. Int. J. Med. Sci. 2021, 18 (2), 520-527. DOI: 10.7150/ijms.50705.

NLM
Chen T, Guo D, Lu J, Xiang B, Li X, Nie J, He X, Li K. The role of chest CT in management of asymptomatic SARS-CoV-2 infections: A longitudinal multi-center study in Chongqing, China. Int J Med Sci 2021; 18(2):520-527. doi:10.7150/ijms.50705. https://www.medsci.org/v18p0520.htm

CSE
Chen T, Guo D, Lu J, Xiang B, Li X, Nie J, He X, Li K. 2021. The role of chest CT in management of asymptomatic SARS-CoV-2 infections: A longitudinal multi-center study in Chongqing, China. Int J Med Sci. 18(2):520-527.

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