ISSN: 1449-1907International Journal of Medical Sciences
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Int J Med Sci 2017; 14(8):729-734. doi:10.7150/ijms.19616 This issue Cite
Research Paper
Anti-inflammatory Effects of the Natural Compounds Cortex Phellodendri and Humulus japonicus on Pelvic Inflammatory Disease in Mice
1. College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University, Chuncheon, 24341, Republic of Korea;
2. College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Abstract
Pelvic inflammatory disease (PID) is an inflammatory and/or infectious disorder of the upper female genital tract, including the uterus, fallopian tubes, and adjacent pelvic structures, that may spread upward to the peritoneum. Currently available treatment options have presented to produce adverse effects of various degrees, such as increased antimicrobial resistance and a limited effective duration of hormones. In the study, the Cortex Phellodendri (CP) and Humulus japonicus (HJ) among natural compounds that are believed to present biological activities with fewer side effects were tested in a PID animal model. The results suggested that the administration CP and HJ reduced clinical signs, inflammatory cytokine expression as well as secretion in uterine tissue, and neutrophil infiltration into the tissue.
Keywords: Pelvic inflammatory disease, Cortex Phellodendri, Humulus japonicus, anti-inflammation.
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