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Int J Med Sci 2024; 21(3):474-482. doi:10.7150/ijms.90145 This issue Cite

Research Paper

Significance of Gastrokine-1 Polymorphism Rs4254535 as a Prognostic Marker and its Association with Clinical Characteristics in Chinese Lung Cancer Patients

Zixiu Zou^1#, Chang Xu^2#, Zhengxing Li^3#, Yajun Yang¹, Yutao Li⁴, Zhenyu Sun⁵, Qiang Li⁶, Miao Li⁷, Yuxin Chen⁸, Gengxi Jiang⁹, Man Xiao¹⁰, Shicheng Guo⁴, Yi Wang⁴, Haijian Wang⁴, Fan Xia^11✉, Yan Shang^12,13✉, Junjie Wu^7,14,4✉

1. School of Life Sciences, Fudan University, Shanghai, 200438, China.
2. Clinical College of Xiangnan University, Chenzhou, 423000, China.
3. Department of Surgery, Navy Military Medical University Affiliated to Changhai Hospital, Shanghai, China.
4. State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics & Development, School of Life Sciences, Fudan University, Shanghai, 200438, China.
5. School of Basic Medicine, Navy Military Medical University, Shanghai, 200433, China.
6. Department of Respiratory and Critical Care Medicine, Shanghai East Hospital, Tongji University, Shanghai, 200120, China.
7. Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
8. Nanjing Medical University, The Fourth Clinical Medical College, Nanjing, 211166, China.
9. Department of Thoracic Surgery, Navy Military Medical University Affiliated Changhai Hospital, Shanghai, 200433, China.
10. Department of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, 571199, China.
11. Department of Respiratory Disease, Navy 905 Hospital, Shanghai, 200235, China.
12. Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, the First Afliated Hospital of Naval Medical University, Shanghai 200433, China.
13. Department of General Medicine, the First Afliated Hospital of Naval Medical University, Shanghai 200433, China.
14. Department of Pulmonary and Critical Care Medicine, Shanghai Geriatric Medical Center, Shanghai, 200032, China.
#These authors contributed equally to this work.

✉ Corresponding author: wjjxcccom (Junjie Wu); xfs2000com (Fan Xia); shangyan751200com (Yan Shang); *Address: Shanghai Geriatric Medical Center, Zhongshan Hospital, Fudan University. No. 512 Huashan Road, Jing'an District, Shanghai, China. More

Abstract

Background: The single nucleotide polymorphism (SNP) of Gastrokine-1 (GKN1) is associated with lung cancer but its association with prognosis is not clear.

Methods: Genomic DNA was extracted from the blood samples of 888 patients with lung cancer. The association between GKN1 polymorphism rs4254535 and prognostic was analyzed by the Kaplan-Meier (KM) method, Log-rank test, and Cox proportional hazards model.

Results: In females and patients diagnosed with late-stage lung cancer, the CC genotype (CC vs TT, adjusted odds ratio [HR] = 0.57, 95% Confidence Interval [CI]: 0.33-0.99, P = 0.045; HR = 0.66, 95% CI: 0.48-0.92, P = 0.014) and recessive CC genotype (CC vs TT + TC, HR = 0.55, 95% CI: 0.32-0.94, P = 0.028; HR = 0.64, 95% CI: 0.47-0.89, P = 0.006) of rs4254535 conferred a better prognosis, compared with the TT and TT + TC genotype. Rs4254535 dominate TC + CC genotype, recessive CC genotype, and C allele who were adenocarcinoma patients had a significantly better prognosis. The recessive CC genotype of non-smoking patients has a better prognosis, compared to the TT + TC genotype. Additionally, in the dominant TT + TC genotype and C allele, no family history patients had a significantly better prognosis, compared to the TT genotype.

Conclusion: For lung cancer patients, GKN1 polymorphism rs4254535 may be a protective genetic marker and predicts the prognosis of lung cancer patients.

Keywords: GKN1, rs4254535, lung cancer, single nucleotide polymorphism, prognosis

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