Int J Med Sci 2022; 19(13):1875-1878. doi:10.7150/ijms.77152 This issue Cite

Research Paper

Prognostic significance of histological grade in low-risk endometrial cancer

Seong Eun Bak1, Ji Geun Yoo2, Sung Jong Lee1, Joo Hee Yoon3, Dong Choon Park3, Sang Il Kim3✉

1. Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
2. Department of Obstetrics and Gynecology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
3. Department of Obstetrics and Gynecology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Citation:
Bak SE, Yoo JG, Lee SJ, Yoon JH, Park DC, Kim SI. Prognostic significance of histological grade in low-risk endometrial cancer. Int J Med Sci 2022; 19(13):1875-1878. doi:10.7150/ijms.77152. https://www.medsci.org/v19p1875.htm
Other styles

File import instruction

Abstract

Graphic abstract

Objective: Investigate the risk factors for recurrence in patients with low-risk endometrial cancer.

Method: A retrospective review was performed to identify patients who underwent primary surgical treatment for endometrial cancer from December 2009 to December 2020. Patients who met the following criteria were included in the study: (a) International Federation of Gynecology and Obstetrics stage IA, (b) endometrioid-type histology, (c) histological grade 1 or 2.

Univariate and multivariate analyses using Cox proportional hazards model to evaluate effects of prognostic factors. Disease-free survival and overall survival were calculated using the Kaplan-Meier method.

Results: A total of 171 patients with low-risk endometrial cancer were included in the study. Recurrence was detected in 9 patients. Histological grade was found to be independent risk factors for recurrence in women with low-risk endometrial cancer (OR 8.255, 95% confidence interval (CI) 1.585 - 42.981; p = 0.012).

Conclusion: The results of this study suggest that grade 2 disease should be considered a significant prognostic factor for the recurrence of low-risk endometrial cancer.

Keywords: endometrial cancer, uterine cancer, low risk, risk factors, histological grade


Citation styles

APA
Bak, S.E., Yoo, J.G., Lee, S.J., Yoon, J.H., Park, D.C., Kim, S.I. (2022). Prognostic significance of histological grade in low-risk endometrial cancer. International Journal of Medical Sciences, 19(13), 1875-1878. https://doi.org/10.7150/ijms.77152.

ACS
Bak, S.E.; Yoo, J.G.; Lee, S.J.; Yoon, J.H.; Park, D.C.; Kim, S.I. Prognostic significance of histological grade in low-risk endometrial cancer. Int. J. Med. Sci. 2022, 19 (13), 1875-1878. DOI: 10.7150/ijms.77152.

NLM
Bak SE, Yoo JG, Lee SJ, Yoon JH, Park DC, Kim SI. Prognostic significance of histological grade in low-risk endometrial cancer. Int J Med Sci 2022; 19(13):1875-1878. doi:10.7150/ijms.77152. https://www.medsci.org/v19p1875.htm

CSE
Bak SE, Yoo JG, Lee SJ, Yoon JH, Park DC, Kim SI. 2022. Prognostic significance of histological grade in low-risk endometrial cancer. Int J Med Sci. 19(13):1875-1878.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.