[6]-Gingerol induces Caspase-Dependent Apoptosis in Bladder Cancer cells via MAPK and ROS Signaling

Choi, Na Ri; Choi, Woo-gyun; Kwon, Min Ji; Woo, Joo Han; Kim, Byung Joo

doi:10.7150/ijms.73077

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Int J Med Sci 2022; 19(7):1093-1102. doi:10.7150/ijms.73077 This issue Cite

Research Paper

[6]-Gingerol induces Caspase-Dependent Apoptosis in Bladder Cancer cells via MAPK and ROS Signaling

Na Ri Choi^1*, Woo-gyun Choi^1*, Min Ji Kwon¹, Joo Han Woo^2,3✉, Byung Joo Kim^1✉

1. Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan 50612, Republic of Korea.
2. Department of Physiology, Dongguk University College of Medicine, Gyeongju, 38066. Republic of Korea.
3. Channelopathy Research Center (CRC), Dongguk University College of Medicine, 32 Dongguk-ro, Ilsan Dong-gu, Goyang, Gyeonggi-do, 10326. Republic of Korea.
*These authors contributed equally to this work.

✉ Corresponding authors: Byung Joo Kim, Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, 49 Busandaehakro, Mulgeum-eup, Yangsan 50612, Republic of Korea. Telephone: +82-51-510-8469; Fax: +82-51-510 More

Citation:

Choi NR, Choi Wg, Kwon MJ, Woo JH, Kim BJ. [6]-Gingerol induces Caspase-Dependent Apoptosis in Bladder Cancer cells via MAPK and ROS Signaling. Int J Med Sci 2022; 19(7):1093-1102. doi:10.7150/ijms.73077. https://www.medsci.org/v19p1093.htm

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Abstract

The anti-cancer effects of [6]-gingerol ([6]-GIN), the main active polyphenol of ginger (Zingiber officinale), were investigated in the human bladder cancer cell line 5637. [6]-GIN inhibited cell proliferation, increased sub‑G1 phase ratios, and depolarized mitochondrial membrane potential. [6]-GIN-induced cell death was associated with the downregulation of B‑cell lymphoma 2 (BCL‑2) and survivin and the upregulation of Bcl‑2‑associated X protein (Bax). [6]-GIN activated caspase‑3 and caspase-9 and regulated the activation of mitogen-activated protein kinases (MAPKs). Further, [6]-GIN also increased the intracellular reactive oxygen species (ROS) levels and TG100-115 or tranilast increased [6]-GIN‑induced cell death. These results suggest that [6]-GIN induced apoptosis in the bladder cancer cell line 5637 and therefore has the potential to be used in the development of new drugs for bladder cancer treatment.

Keywords: [6]-gingerol, cell proliferation, apoptosis, bladder cancer, 5637

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APA

Choi, N.R., Choi, W.g., Kwon, M.J., Woo, J.H., Kim, B.J. (2022). [6]-Gingerol induces Caspase-Dependent Apoptosis in Bladder Cancer cells via MAPK and ROS Signaling. International Journal of Medical Sciences, 19(7), 1093-1102. https://doi.org/10.7150/ijms.73077.

ACS

Choi, N.R.; Choi, W.g.; Kwon, M.J.; Woo, J.H.; Kim, B.J. [6]-Gingerol induces Caspase-Dependent Apoptosis in Bladder Cancer cells via MAPK and ROS Signaling. Int. J. Med. Sci. 2022, 19 (7), 1093-1102. DOI: 10.7150/ijms.73077.

NLM

CSE

Choi NR, Choi Wg, Kwon MJ, Woo JH, Kim BJ. 2022. [6]-Gingerol induces Caspase-Dependent Apoptosis in Bladder Cancer cells via MAPK and ROS Signaling. Int J Med Sci. 19(7):1093-1102.

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