Int J Med Sci 2022; 19(6):1013-1022. doi:10.7150/ijms.72378 This issue Cite
Research Paper
1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
2. Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan
3. Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan
4. School of Medicine, Chung Shan Medical University, Taichung, Taiwan
5. Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan
6. Department of Medicine, National Taiwan University, Taipei, Taiwan
7. Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan
8. Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan
9. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan
#Equal contribution as first authors
Single nucleotide polymorphisms (SNPs) of tissue inhibitor of metalloproteinases-3 (TIMP-3) have been revealed to be related to various cancers. To date, no study explores the relationships between TIMP-3 polymorphisms and uterine cervical cancer. The purposes of this research were to investigate the associations among genetic variants of TIMP-3 and development and clinicopathological factors of uterine cervical cancer, and patient 5 years survival in Taiwanese women. The study included 123 patients with invasive cancer and 97 with precancerous lesions of uterine cervix, and 300 control women. TIMP-3 polymorphisms rs9619311, rs9862 and rs11547635 were checked and their genotypic distributions were determined by real-time polymerase chain reaction. It showed that women with genotypes CT/TT in rs9862 were found to display a higher risk of developing cervical cancer with moderate and poor cell differentiation. Moreover, it revealed that cervical cancer patients carrying genotypes CC in rs9619311 exhibited a poorer 5 years survival, as compared to those with TT/TC in Taiwanese women, using univariate analysis. In addition, pelvic lymph node metastasis was determined to independently predict 5 years survival in cervical cancer patients using multivariate analysis. Conclusively, TIMP-3 SNPs polymorphisms rs9619311 are related to cervical patient survival in Taiwanese women.
Keywords: tissue inhibitor of metalloproteinases-3, single nucleotide polymorphisms, uterine cervical cancer, lymph node metastasis, 5 years survival