Effect of tissue inhibitor of metalloproteinases-3 genetics polymorphism on clinicopathological characteristics of uterine cervical cancer patients in Taiwan

Chung, Jui-Fu; Chen, Chia-Lin; Nassef, Yasser; Shiu, Bei-Hao; Wang, Chun-Hao; Kuo, Fu-Hsuan; Hsiao, Yi-Hsuan; Yang, Shun-Fa; Wang, Po-Hui

doi:10.7150/ijms.72378

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Int J Med Sci 2022; 19(6):1013-1022. doi:10.7150/ijms.72378 This issue Cite

Research Paper

Effect of tissue inhibitor of metalloproteinases-3 genetics polymorphism on clinicopathological characteristics of uterine cervical cancer patients in Taiwan

Jui-Fu Chung^1,2,#, Chia-Lin Chen^3,4,#, Yasser Nassef¹, Bei-Hao Shiu^1,4,5, Chun-Hao Wang⁶, Fu-Hsuan Kuo^1,7, Yi-Hsuan Hsiao^4,8, Shun-Fa Yang^1,9, Po-Hui Wang^1,3,4,✉

1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
2. Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan
3. Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan
4. School of Medicine, Chung Shan Medical University, Taichung, Taiwan
5. Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan
6. Department of Medicine, National Taiwan University, Taipei, Taiwan
7. Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan
8. Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan
9. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan
^#Equal contribution as first authors

Citation:

Chung JF, Chen CL, Nassef Y, Shiu BH, Wang CH, Kuo FH, Hsiao YH, Yang SF, Wang PH. Effect of tissue inhibitor of metalloproteinases-3 genetics polymorphism on clinicopathological characteristics of uterine cervical cancer patients in Taiwan. Int J Med Sci 2022; 19(6):1013-1022. doi:10.7150/ijms.72378. https://www.medsci.org/v19p1013.htm

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Abstract

Single nucleotide polymorphisms (SNPs) of tissue inhibitor of metalloproteinases-3 (TIMP-3) have been revealed to be related to various cancers. To date, no study explores the relationships between TIMP-3 polymorphisms and uterine cervical cancer. The purposes of this research were to investigate the associations among genetic variants of TIMP-3 and development and clinicopathological factors of uterine cervical cancer, and patient 5 years survival in Taiwanese women. The study included 123 patients with invasive cancer and 97 with precancerous lesions of uterine cervix, and 300 control women. TIMP-3 polymorphisms rs9619311, rs9862 and rs11547635 were checked and their genotypic distributions were determined by real-time polymerase chain reaction. It showed that women with genotypes CT/TT in rs9862 were found to display a higher risk of developing cervical cancer with moderate and poor cell differentiation. Moreover, it revealed that cervical cancer patients carrying genotypes CC in rs9619311 exhibited a poorer 5 years survival, as compared to those with TT/TC in Taiwanese women, using univariate analysis. In addition, pelvic lymph node metastasis was determined to independently predict 5 years survival in cervical cancer patients using multivariate analysis. Conclusively, TIMP-3 SNPs polymorphisms rs9619311 are related to cervical patient survival in Taiwanese women.

Keywords: tissue inhibitor of metalloproteinases-3, single nucleotide polymorphisms, uterine cervical cancer, lymph node metastasis, 5 years survival

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APA

Chung, J.F., Chen, C.L., Nassef, Y., Shiu, B.H., Wang, C.H., Kuo, F.H., Hsiao, Y.H., Yang, S.F., Wang, P.H. (2022). Effect of tissue inhibitor of metalloproteinases-3 genetics polymorphism on clinicopathological characteristics of uterine cervical cancer patients in Taiwan. International Journal of Medical Sciences, 19(6), 1013-1022. https://doi.org/10.7150/ijms.72378.

ACS

Chung, J.F.; Chen, C.L.; Nassef, Y.; Shiu, B.H.; Wang, C.H.; Kuo, F.H.; Hsiao, Y.H.; Yang, S.F.; Wang, P.H. Effect of tissue inhibitor of metalloproteinases-3 genetics polymorphism on clinicopathological characteristics of uterine cervical cancer patients in Taiwan. Int. J. Med. Sci. 2022, 19 (6), 1013-1022. DOI: 10.7150/ijms.72378.

NLM

CSE

Chung JF, Chen CL, Nassef Y, Shiu BH, Wang CH, Kuo FH, Hsiao YH, Yang SF, Wang PH. 2022. Effect of tissue inhibitor of metalloproteinases-3 genetics polymorphism on clinicopathological characteristics of uterine cervical cancer patients in Taiwan. Int J Med Sci. 19(6):1013-1022.

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