Int J Med Sci 2022; 19(6):1003-1012. doi:10.7150/ijms.71971 This issue Cite

Research Paper

Nomograms based on lactate dehydrogenase to albumin ratio for predicting survival in colorectal cancer

Yugang Hu1*, Yanxiang Zhou1*, Yinghao Cao2, Hao Wang1, Yuanting Yang1, Riyue Jiang1, Qincheng Gong1, Qing Zhou1✉

1. Department of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan, China; 430061
2. Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; 430022
*Contributed equally to this manuscript.

Citation:
Hu Y, Zhou Y, Cao Y, Wang H, Yang Y, Jiang R, Gong Q, Zhou Q. Nomograms based on lactate dehydrogenase to albumin ratio for predicting survival in colorectal cancer. Int J Med Sci 2022; 19(6):1003-1012. doi:10.7150/ijms.71971. https://www.medsci.org/v19p1003.htm
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Abstract

Graphic abstract

Purpose: We aimed to determine if lactate dehydrogenase to albumin ratio (LAR) might play a prognostic role for patients with operable colorectal cancer (CRC).

Patients and Methods: 1334 operable CRC patients in Wuhan Union Hospital Between July 2013 and September 2017 were enrolled in this study and were randomly appointed them into training (n=954) and validation (n=380) sets. The relationship between LAR and overall survival (OS) and disease-free survival (DFS) were determined by restricted cubic splines (RCS) with Cox regression models. LAR was then divided into three categories based on the RCS and compared to the well-known TNM stage system. Finally, survival nomograms were developed by compounding the LAR and other clinical factors.

Results: Baseline LAR values and the all-cause mortality were U shaped, which slowly decreased until around 4.50 and then started to increase rapidly when the LAR ranged from 4.50-6.68 and then became flat thereafter (P for non-linearity <0.001). LAR was superior to TNM stage for OS as well as DFS and LAR plus TNM stage could add more net benefit than clinical model alone. Moreover, the survival nomograms based on LAR achieved great predictive ability for OS and DFS in operable CRC patients.

Conclusions: LAR could be served as a reliable prognostic factor for OS as well as DFS, with more accurate prognostic prediction than current TNM stage for patients with operable CRC.

Keywords: colorectal cancer, lactate dehydrogenase to albumin ratio, prognosis, inflammation, survival nomogram


Citation styles

APA
Hu, Y., Zhou, Y., Cao, Y., Wang, H., Yang, Y., Jiang, R., Gong, Q., Zhou, Q. (2022). Nomograms based on lactate dehydrogenase to albumin ratio for predicting survival in colorectal cancer. International Journal of Medical Sciences, 19(6), 1003-1012. https://doi.org/10.7150/ijms.71971.

ACS
Hu, Y.; Zhou, Y.; Cao, Y.; Wang, H.; Yang, Y.; Jiang, R.; Gong, Q.; Zhou, Q. Nomograms based on lactate dehydrogenase to albumin ratio for predicting survival in colorectal cancer. Int. J. Med. Sci. 2022, 19 (6), 1003-1012. DOI: 10.7150/ijms.71971.

NLM
Hu Y, Zhou Y, Cao Y, Wang H, Yang Y, Jiang R, Gong Q, Zhou Q. Nomograms based on lactate dehydrogenase to albumin ratio for predicting survival in colorectal cancer. Int J Med Sci 2022; 19(6):1003-1012. doi:10.7150/ijms.71971. https://www.medsci.org/v19p1003.htm

CSE
Hu Y, Zhou Y, Cao Y, Wang H, Yang Y, Jiang R, Gong Q, Zhou Q. 2022. Nomograms based on lactate dehydrogenase to albumin ratio for predicting survival in colorectal cancer. Int J Med Sci. 19(6):1003-1012.

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