Int J Med Sci 2022; 19(4):659-668. doi:10.7150/ijms.64133 This issue Cite

Review

The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers

Qingshang Li, Zhijun Cao, Shuliang Zhao

Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease; State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health. 145 Middle Shandong Road, Shanghai, China.

Citation:
Li Q, Cao Z, Zhao S. The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. Int J Med Sci 2022; 19(4):659-668. doi:10.7150/ijms.64133. https://www.medsci.org/v19p0659.htm
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Abstract

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Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. Here we review GFRα biological functions and discussed the evidence indicating whether GFRα signaling complex present novel opportunities for oncogenic intervention and treatment resistance. Thus, our work systematically reviewed the emerging role of GFRα family members in cancers, and provided novel insights for further researches.

Keywords: GFRα1, GDNF, cancer, neural invasion, treatment resistance


Citation styles

APA
Li, Q., Cao, Z., Zhao, S. (2022). The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. International Journal of Medical Sciences, 19(4), 659-668. https://doi.org/10.7150/ijms.64133.

ACS
Li, Q.; Cao, Z.; Zhao, S. The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. Int. J. Med. Sci. 2022, 19 (4), 659-668. DOI: 10.7150/ijms.64133.

NLM
Li Q, Cao Z, Zhao S. The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. Int J Med Sci 2022; 19(4):659-668. doi:10.7150/ijms.64133. https://www.medsci.org/v19p0659.htm

CSE
Li Q, Cao Z, Zhao S. 2022. The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. Int J Med Sci. 19(4):659-668.

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