Int J Med Sci 2021; 18(16):3708-3711. doi:10.7150/ijms.62193 This issue

Research Paper

Bacterial contamination of lightproof covers for high-calorie infusion solutions in wards

Kengo Hosomi1,2, Yuko Takasu3, Yumiko Hisai1, Sachiko Komaki1, Hiroaki Otsuki1, Kyoko Okimoto4, Sachiko Omotani2, Yasutoshi Hatsuda2, Michiaki Myotoku2✉

1. Department of Pharmacy, Kawanishi City Hospital.
2. Faculty of Pharmacy, Osaka Ohtani University.
3. Department of Pharmacy, Takarazuka City Hospital.
4. Department of Clinical Laboratory, Kawanishi City Hospital.

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Hosomi K, Takasu Y, Hisai Y, Komaki S, Otsuki H, Okimoto K, Omotani S, Hatsuda Y, Myotoku M. Bacterial contamination of lightproof covers for high-calorie infusion solutions in wards. Int J Med Sci 2021; 18(16):3708-3711. doi:10.7150/ijms.62193. Available from

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Graphic abstract

Deterioration of drugs due to light exposure is one of the major concerns, especially regarding protection of high-calorie infusion solutions, lightproof covers are used in hospitals. In the absence of any set standards regarding their usage, they are often reused. This study aimed to investigate bacterial contamination of lightproof covers used in hospital wards. For this, lightproof covers which had been used or stored in wards were collected and bacterial cultures were carried out from them. Examination of the cultures revealed that bacteria were present in the used lightproof covers. The bacterial species detected in the used lightproof covers were Bacillus species Coagulase-negative Staphylococci (CNS) and Methicillin-resistant Staphylococcus aureus (MRSA). Bacillus species and CNS were also detected in lightproof covers stored in wards, whereas MRSA was not detected. Intestinal bacteria were detected in only one lightproof cover. However, no bacteria were detected from either inside or outside of the unused lightproof covers that were stored in the drugs department. After allowing the unused lightproof covers stored in the drugs department to stand for 24 h, Bacillus species and CNS were detected in only one of the covers, whereas no bacteria was detected in other covers. These results indicate that there is a risk of bacterial contamination in the reuse of lightproof covers and that they should either be disposed off properly after usage or hand, finger disinfectants should be used while handling them to prevent any possible contamination.

Keywords: lightproof covers, high-calorie infusion solutions, bacterial contamination, Bacillus species, Coagulase-negative staphylococci, Methicillin-resistant Staphylococcus aureus