ISSN: 1449-1907International Journal of Medical Sciences
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Int J Med Sci 2021; 18(8):1877-1885. doi:10.7150/ijms.52177 This issue Cite
Research Paper
Hydroxyurea regulates the development and survival of B16 Melanoma Cells by upregulating MiR-7013-3p
Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, Jilin, P.R. China.
Citation:
Huang YJ, Gao Y, Wang CJ, Han DX, Zheng Y, Wang WH, Jiang H, Yuan B, Zhang JB. Hydroxyurea regulates the development and survival of B16 Melanoma Cells by upregulating MiR-7013-3p. Int J Med Sci 2021; 18(8):1877-1885. doi:10.7150/ijms.52177. https://www.medsci.org/v18p1877.htm
Other stylesAbstract
miRNAs are a family of short, noncoding RNAs that are involved in many processes in melanoma cells. MITF acts as a master regulator of melanocyte function, development and survival by modulating various genes. Hydroxyurea (HU) is used to treat melanoma, and miRNA expression is altered after HU treatment in B16 melanoma cells. In this study, we screened for miRNAs that were upregulated after HU treatment and that targeted the MITF gene. We found that miR-7013-3p exhibited increased expression after HU treatment and could bind to MITF. miR-7013-3p inhibited melanin production, proliferation, and migration and promoted apoptosis in B16 melanoma cells. The results may provide more information on the roles of miR-7013-3p in B16 melanoma cells.
Keywords: miR-7013-3p, B16 melanoma cells, MITF, hydroxyurea (HU), pigmentation
Citation styles
APA
Huang, Y.J., Gao, Y., Wang, C.J., Han, D.X., Zheng, Y., Wang, W.H., Jiang, H., Yuan, B., Zhang, J.B. (2021). Hydroxyurea regulates the development and survival of B16 Melanoma Cells by upregulating MiR-7013-3p. International Journal of Medical Sciences, 18(8), 1877-1885. https://doi.org/10.7150/ijms.52177.
ACS
Huang, Y.J.; Gao, Y.; Wang, C.J.; Han, D.X.; Zheng, Y.; Wang, W.H.; Jiang, H.; Yuan, B.; Zhang, J.B. Hydroxyurea regulates the development and survival of B16 Melanoma Cells by upregulating MiR-7013-3p. Int. J. Med. Sci. 2021, 18 (8), 1877-1885. DOI: 10.7150/ijms.52177.
NLM
Huang YJ, Gao Y, Wang CJ, Han DX, Zheng Y, Wang WH, Jiang H, Yuan B, Zhang JB. Hydroxyurea regulates the development and survival of B16 Melanoma Cells by upregulating MiR-7013-3p. Int J Med Sci 2021; 18(8):1877-1885. doi:10.7150/ijms.52177. https://www.medsci.org/v18p1877.htm
CSE
Huang YJ, Gao Y, Wang CJ, Han DX, Zheng Y, Wang WH, Jiang H, Yuan B, Zhang JB. 2021. Hydroxyurea regulates the development and survival of B16 Melanoma Cells by upregulating MiR-7013-3p. Int J Med Sci. 18(8):1877-1885.
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