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Int J Med Sci 2021; 18(6):1339-1347. doi:10.7150/ijms.49997 This issue Cite

Research Paper

Research on the circadian clock gene HNF4a in different malignant tumors

Meng-jun Qiu1, Li Zhang1, Xie-fan Fang2, Qiu-ting Li1, Li-sheng Zhu3, Bin Zhang3, Sheng-li Yang3✉, Zhi-fan Xiong1✉

1. Division of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China.
2. Charles River Laboratories, Inc., 6995 Longley Lane, Reno NV 89511.
3. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

✉ Corresponding authors: Dr. Sheng-li Yang, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China, E-mail: yangshengliedu.cn. And to Prof. Zhi-fan Xiong, Division of Gastroenter More

Citation:
Qiu Mj, Zhang L, Fang Xf, Li Qt, Zhu Ls, Zhang B, Yang Sl, Xiong Zf. Research on the circadian clock gene HNF4a in different malignant tumors. Int J Med Sci 2021; 18(6):1339-1347. doi:10.7150/ijms.49997. https://www.medsci.org/v18p1339.htm
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Abstract

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Background: The circadian rhythm is produced by multiple feedback loops formed by the core clock genes after transcription and translation, thus regulating various metabolic and physiological functions of the human body. We have shown previously that the abnormal expression of 14 clock genes is related closely to the occurrence and development of different malignant tumors, and these genes may play an anti-cancer or pro-cancer role in different tumors. HNF4a has many typical properties of clock proteins involved in the clock gene negative feedback loop regulation process. We need to explore the function of HNF4a as a circadian clock gene in malignant tumors further. Methods: We used The Cancer Genome Atlas (TCGA) database to download the clinicopathological information of twenty malignant tumors and the corresponding RNA-seq data. The HNF4a RNA-seq data standardized by R language and clinical information were integrated to reveal the relationship between HNF4a and prognosis of patients. Results: Analysis of TCGA data showed that the prognosis of HNF4a was significantly different in BLCA, KIRC, LUSC, and READ. High HNF4a expression is correlated with good prognosis in BLCA, KIRC, and READ but poor prognosis in LUSC. However, HNF4a was associated with the stages, T stages, and lymph node status only in BLCA. Conclusions: HNF4a plays different roles in different malignancies, and the abnormal expression of HNF4a has a great correlation with the biological characteristics of BLCA. The low expression of HNF4a could be a reference index for the metastasis, recurrence, and prognosis of BLCA.

Keywords: circadian clock, HNF4a, malignant tumors, prognosis.

Citation styles

APA
Qiu, M.j., Zhang, L., Fang, X.f., Li, Q.t., Zhu, L.s., Zhang, B., Yang, S.l., Xiong, Z.f. (2021). Research on the circadian clock gene HNF4a in different malignant tumors. International Journal of Medical Sciences, 18(6), 1339-1347. https://doi.org/10.7150/ijms.49997.

ACS
Qiu, M.j.; Zhang, L.; Fang, X.f.; Li, Q.t.; Zhu, L.s.; Zhang, B.; Yang, S.l.; Xiong, Z.f. Research on the circadian clock gene HNF4a in different malignant tumors. Int. J. Med. Sci. 2021, 18 (6), 1339-1347. DOI: 10.7150/ijms.49997.

NLM
Qiu Mj, Zhang L, Fang Xf, Li Qt, Zhu Ls, Zhang B, Yang Sl, Xiong Zf. Research on the circadian clock gene HNF4a in different malignant tumors. Int J Med Sci 2021; 18(6):1339-1347. doi:10.7150/ijms.49997. https://www.medsci.org/v18p1339.htm

CSE
Qiu Mj, Zhang L, Fang Xf, Li Qt, Zhu Ls, Zhang B, Yang Sl, Xiong Zf. 2021. Research on the circadian clock gene HNF4a in different malignant tumors. Int J Med Sci. 18(6):1339-1347.

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