Int J Med Sci 2021; 18(3):660-671. doi:10.7150/ijms.52706 This issue

Research Paper

Meta-analysis of the Diagnostic Performance of Circulating MicroRNAs for Pancreatic Cancer

Cheng Peng1, Jiale Wang1, Wenzhe Gao1, Lihua Huang2, Yunfei Liu1, Xia Li3, Zhiqiang Li1,✉, Xiao Yu1,✉

1. Department of Hepatopancreatobiliary Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
2. Center for Medical Experiments, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
3. Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.

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Citation:
Peng C, Wang J, Gao W, Huang L, Liu Y, Li X, Li Z, Yu X. Meta-analysis of the Diagnostic Performance of Circulating MicroRNAs for Pancreatic Cancer. Int J Med Sci 2021; 18(3):660-671. doi:10.7150/ijms.52706. Available from https://www.medsci.org/v18p0660.htm

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Abstract

Background: Numerous studies have suggested that differentially expressed miRNAs may be promising diagnostic markers for pancreatic cancer (PC), but the results are inconsistent. We aimed to summarize the diagnostic accuracy of circulating miRNAs, carbohydrate antigen 19-9 (CA19-9), and the combination of miRNAs and CA19-9.

Material and Methods: A literature search of online databases including PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI) and WanFang was conducted. Relative data were extracted from eligible included studies, and a meta-analysis was performed.

Results: A total of 46 studies involving 4,326 PC patients and 4,277 non-PC controls were included. The pooled sensitivity (SEN), specificity (SPE) and AUC of the circulating miRNAs for differentiating PC patients from non-PC controls were 0.79 (0.77-0.81), 0.77 (0.75-0.79), and 0.85 (0.81-0.87), respectively. The combination of miRNAs and CA19-9 greatly improved the SEN, SPE and AUC to 0.84 (0.80-0.87), 0.91 (0.89-0.93) and 0.94 (0.92-0.96), respectively. Moreover, circulating miRNAs also yielded an acceptable diagnostic accuracy for early-stage PC with a SEN of 0.79 (0.76-0.82), a SPE of 0.74 (0.68-0.79) and an AUC of 0.81 (0.77-0.84).

Conclusion: Circulating miRNAs exhibited satisfactory diagnostic performance for PC and even early-stage PC. The combination of circulating miRNAs and CA19-9 can further improve the diagnostic accuracy, providing a novel strategy for PC diagnosis.

Keywords: pancreatic cancer, microRNAs, diagnosis, meta-analysis, circulating