Using CHADS2, R2CHADS2, CHA2DS2-VASc score for mortality prediction in patients with abnormal low and high ankle-brachial index

Chi, Nai-Yu; Su, Ho-Ming; Lee, Wen-Hsien; Tsai, Wei-Chung; Chen, Ying-Chih; Lin, Tzu-Chieh; Lu, Ye-Hsu; Lee, Chee-Siong; Lin, Tsung-Hsien; Lai, Wen-Ter; Sheu, Sheng-Hsiung; Hsu, Po-Chao

doi:10.7150/ijms.49018

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Int J Med Sci 2021; 18(1):276-283. doi:10.7150/ijms.49018 This issue Cite

Research Paper

Using CHADS₂, R₂CHADS₂, CHA₂DS₂-VASc score for mortality prediction in patients with abnormal low and high ankle-brachial index

Nai-Yu Chi^1,4, Ho-Ming Su^1,2,3, Wen-Hsien Lee^1,2,3, Wei-Chung Tsai^1,2, Ying-Chih Chen^1,3, Tzu-Chieh Lin^1,4, Ye-Hsu Lu¹, Chee-Siong Lee^1,2, Tsung-Hsien Lin^1,2, Wen-Ter Lai^1,2, Sheng-Hsiung Sheu^1,2, Po-Chao Hsu^1,2✉

1. Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
2. Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
3. Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.
4. Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.

Citation:

Chi NY, Su HM, Lee WH, Tsai WC, Chen YC, Lin TC, Lu YH, Lee CS, Lin TH, Lai WT, Sheu SH, Hsu PC. Using CHADS₂, R₂CHADS₂, CHA₂DS₂-VASc score for mortality prediction in patients with abnormal low and high ankle-brachial index. Int J Med Sci 2021; 18(1):276-283. doi:10.7150/ijms.49018. https://www.medsci.org/v18p0276.htm

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Abstract

Abnormal low and high ankle brachial index (ABI) is regarded as peripheral artery disease (PAD) which has extremely high morbidity and mortality. How to identify high-risk PAD patients with increased mortality is very important to improve the outcome. CHADS₂, R₂CHADS₂, and CHA₂DS₂-VASc score are clinically useful scores to evaluate the annual risk of stroke in patients with atrial fibrillation. However, there was no literature discussing the usefulness of these scores for cardiovascular (CV) and all-cause mortality prediction in the patients with abnormal ABI. This longitudinal study enrolled 195 patients with abnormal low (< 0.9) and high ABI (> 1.3). CHADS₂, R₂CHADS₂, and CHA₂DS₂-VASc score were calculated for each patient. CV and all-cause mortality data were collected for outcome prediction. The median follow-up to mortality was 90 months. After multivariate analysis, CHADS₂, R₂CHADS₂, and CHA₂DS₂-VASc score were significant predictors of CV and all-cause mortality (all P < 0.001). CHA₂DS₂-VASc score had a better additive predictive value than CHADS₂ and R₂CHADS₂ score for CV mortality prediction. R₂CHADS₂ and CHA₂DS₂-VASc score had better additive predictive values than CHADS₂ score for all-cause mortality prediction. In conclusion, our study is the first study to investigate the usefulness of CHADS₂, R₂CHADS₂, and CHA₂DS₂-VASc score for mortality prediction in patients with abnormal ABI. Our study showed all three scores are significant predictors for CV and all-cause mortality although there are some differences between the scores. Therefore, using the three scoring systems may help physicians to identify the high-risk PAD patients with increased mortality.

Keywords: all-cause mortality, cardiovascular mortality, CHADS₂ score, CHA₂DS₂-VASc score, chronic kidney disease, R₂CHADS₂ score

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APA

Chi, N.Y., Su, H.M., Lee, W.H., Tsai, W.C., Chen, Y.C., Lin, T.C., Lu, Y.H., Lee, C.S., Lin, T.H., Lai, W.T., Sheu, S.H., Hsu, P.C. (2021). Using CHADS₂, R₂CHADS₂, CHA₂DS₂-VASc score for mortality prediction in patients with abnormal low and high ankle-brachial index. International Journal of Medical Sciences, 18(1), 276-283. https://doi.org/10.7150/ijms.49018.

ACS

Chi, N.Y.; Su, H.M.; Lee, W.H.; Tsai, W.C.; Chen, Y.C.; Lin, T.C.; Lu, Y.H.; Lee, C.S.; Lin, T.H.; Lai, W.T.; Sheu, S.H.; Hsu, P.C. Using CHADS₂, R₂CHADS₂, CHA₂DS₂-VASc score for mortality prediction in patients with abnormal low and high ankle-brachial index. Int. J. Med. Sci. 2021, 18 (1), 276-283. DOI: 10.7150/ijms.49018.

NLM

CSE

Chi NY, Su HM, Lee WH, Tsai WC, Chen YC, Lin TC, Lu YH, Lee CS, Lin TH, Lai WT, Sheu SH, Hsu PC. 2021. Using CHADS₂, R₂CHADS₂, CHA₂DS₂-VASc score for mortality prediction in patients with abnormal low and high ankle-brachial index. Int J Med Sci. 18(1):276-283.

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