Int J Med Sci
2020; 17(18):2974-2986.
doi:10.7150/ijms.50537 This issueCite
Review
Clinical Outcomes of COVID-19 Patients with Pre-existing, Compromised Immune Systems: A Review of Case Reports
Tanner Corse1*, Linda Dayan1*, Sydney Kersten1*, Fortunato Battaglia2, Stanley R Terlecky2, Zhiyong Han2✉
1. Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA 2. Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA. *These authors contributed equally
✉ Corresponding author: Zhiyong Han, Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA. Email: zhiyong.hanorg; Tel: 01-973-275-4309
Citation:
Corse T, Dayan L, Kersten S, Battaglia F, Terlecky SR, Han Z. Clinical Outcomes of COVID-19 Patients with Pre-existing, Compromised Immune Systems: A Review of Case Reports. Int J Med Sci 2020; 17(18):2974-2986. doi:10.7150/ijms.50537. https://www.medsci.org/v17p2974.htm
In the ongoing COVID-19 pandemic, all COVID-19 patients are naïve patients as it is the first-time humans have been exposed to the SARS-CoV-2 virus. As with exposure to many viruses, individuals with pre-existing, compromised immune systems may be at increased risk of developing severe symptoms and/or dying because of (SARS-CoV-2) infection. To learn more about such individuals, we conducted a search and review of published reports on the clinical characteristics and outcomes of COVID-19 patients with pre-existing, compromised immune systems. Here we present our review of patients who possess pre-existing primary antibody deficiency (PAD) and those who are organ transplant recipients on maintenance immunosuppressants. Our review indicates different clinical outcomes for the patients with pre-existing PAD, depending on the underlying causes. For organ transplant recipients, drug-induced immune suppression alone does not appear to enhance COVID-19 mortality risk - rather, advanced age, comorbidities, and the development of secondary complications appears required.
Citation styles
APA
Corse, T., Dayan, L., Kersten, S., Battaglia, F., Terlecky, S.R., Han, Z. (2020). Clinical Outcomes of COVID-19 Patients with Pre-existing, Compromised Immune Systems: A Review of Case Reports. International Journal of Medical Sciences, 17(18), 2974-2986. https://doi.org/10.7150/ijms.50537.
ACS
Corse, T.; Dayan, L.; Kersten, S.; Battaglia, F.; Terlecky, S.R.; Han, Z. Clinical Outcomes of COVID-19 Patients with Pre-existing, Compromised Immune Systems: A Review of Case Reports. Int. J. Med. Sci. 2020, 17 (18), 2974-2986. DOI: 10.7150/ijms.50537.
NLM
Corse T, Dayan L, Kersten S, Battaglia F, Terlecky SR, Han Z. Clinical Outcomes of COVID-19 Patients with Pre-existing, Compromised Immune Systems: A Review of Case Reports. Int J Med Sci 2020; 17(18):2974-2986. doi:10.7150/ijms.50537. https://www.medsci.org/v17p2974.htm
CSE
Corse T, Dayan L, Kersten S, Battaglia F, Terlecky SR, Han Z. 2020. Clinical Outcomes of COVID-19 Patients with Pre-existing, Compromised Immune Systems: A Review of Case Reports. Int J Med Sci. 17(18):2974-2986.
This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
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