Int J Med Sci 2020; 17(17):2861-2868. doi:10.7150/ijms.48882 This issue Cite

Research Paper

Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration: A single-center analysis

Songming Ding1#, Aili Lu2#, Xinhua Chen3, Bingqian Xu1, Ning Wu1, Muhammad Ibrahim Alhadi Edoo3, Shusen Zheng1,3, Qiyong Li1✉

1. Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University, Shulan International Medical College, #848 Dongxin Road, Hangzhou, Zhejiang, P.R. China.
2. Division of oncology department, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China.
3. Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, ZhejiangUniversity School of Medicine, Hangzhou, Zhejiang, P.R. China.
#Equal contributors to this work.

Citation:
Ding S, Lu A, Chen X, Xu B, Wu N, Edoo MIA, Zheng S, Li Q. Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration: A single-center analysis. Int J Med Sci 2020; 17(17):2861-2868. doi:10.7150/ijms.48882. https://www.medsci.org/v17p2861.htm
Other styles

File import instruction

Abstract

Background: Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) has become an important modality for identification of intra-abdominal masses. This study analyzed the accuracy of EUS-FNAB in a single medical center and explored factors related to positive diagnosis.

Materials and methods: In total, 77 patients with EUS-FNAB were retrospectively reviewed from July 2016 to February 2020. “Atypical (tends to be neoplasm/malignancy),” “suspicious (first consider neoplasm/malignancy),” and “malignant” were defined as positive cytology. The final diagnoses were based on histopathologic examination. The positive rate of EUS-FNAB for the diagnosis of neoplasm and its associations with age, sex, target puncture mass size, liver function, tumor markers, albumin, hypertension, and diabetes were examined.

Results: Accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of EUS-FNAB cytologic diagnoses in all patients were 77.9% (60/77), 76.1% (54/71), 100%, 100%, and 26.1% (6/23), respectively. Accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of EUS-FNAB cytologic diagnoses in the pancreas were 80.0% (48/60), 79.3% (46/58), 100%, 100%, and 14.3% (2/14), respectively. The results of EUS-FNAB in pancreatic masses showed that the level of CA19-9 was higher in the true positive group than in the false-negative group (p<0.05). There were no factors associated with the true positive cytologic diagnoses (p>0.05).

Conclusions: Our single-medical center study showed that EUS-FNAB is an accurate diagnostic procedure for the evaluation of intra-abdominal masses. Further follow-up is required to explore factors associated with the true positive cytology.

Keywords: Endoscopic ultrasound, fine needle aspiration biopsy, cytology, pancreas


Citation styles

APA
Ding, S., Lu, A., Chen, X., Xu, B., Wu, N., Edoo, M.I.A., Zheng, S., Li, Q. (2020). Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration: A single-center analysis. International Journal of Medical Sciences, 17(17), 2861-2868. https://doi.org/10.7150/ijms.48882.

ACS
Ding, S.; Lu, A.; Chen, X.; Xu, B.; Wu, N.; Edoo, M.I.A.; Zheng, S.; Li, Q. Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration: A single-center analysis. Int. J. Med. Sci. 2020, 17 (17), 2861-2868. DOI: 10.7150/ijms.48882.

NLM
Ding S, Lu A, Chen X, Xu B, Wu N, Edoo MIA, Zheng S, Li Q. Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration: A single-center analysis. Int J Med Sci 2020; 17(17):2861-2868. doi:10.7150/ijms.48882. https://www.medsci.org/v17p2861.htm

CSE
Ding S, Lu A, Chen X, Xu B, Wu N, Edoo MIA, Zheng S, Li Q. 2020. Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration: A single-center analysis. Int J Med Sci. 17(17):2861-2868.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.