ISSN: 1449-1907International Journal of Medical Sciences
Global reach, higher impact
Int J Med Sci 2020; 17(8):1095-1101. doi:10.7150/ijms.44439 This issue Cite
Review
The Role of Cyclooxygenase-2 in Colorectal Cancer
1. Department of Gastroenterology, the Second People's Hospital of Yunnan Province, Kunming, Yunnan 650021, China
2. The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China
3. Department of General Surgery, The Second People's Hospital of Yunnan Province, Kunming, Yunnan 650021, China
4. Tissue Tech Inc, Miami, Florida 33032, USA
*The first three authors contribute equally to this work.
Abstract
Colorectal cancer is the third common cancer in this world, accounting for more than 1 million cases each year. However, detailed etiology and mechanism of colorectal cancer have not been fully understood. For example, cyclooxygenase-2 (COX-2) and its product prostaglandin E2 (PGE2) have been closely linked to its occurrence, progression and prognosis. However, the mechanisms on how COX-2 and PGE2-mediate the pathogenesis of colorectal cancer are obscure. In this review, we have summarized recent advances in studies of pathogenesis and control in colorectal cancer to assist further advances in the research for the cure of the cancer. In addition, the knowledge gained may also guide the audiences for reduction of the risk and control of this deadly disease.
Keywords: cancer, colon, cyclooxygenase-2, invasion, prostaglandin
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