Int J Med Sci 2019; 16(6):845-853. doi:10.7150/ijms.32505 This issue Cite

Research Paper

A Combination of Tamarindus indica seeds and Curcuma longa Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity

Posani Srinivas Rao1, Yendluri Sita Ramanjaneyulu1, Victor R Prisk2, Leon J Schurgers3✉

1. Sravani Hospital; Guntur-522001 Andhra Pradesh, India
2. Prisk Orthopaedics and Wellness, PC Monroeville, PA
3. Department of Biochemistry, Maastricht University, Maastricht, The Netherlands.

Citation:
Rao PS, Ramanjaneyulu YS, Prisk VR, Schurgers LJ. A Combination of Tamarindus indica seeds and Curcuma longa Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity. Int J Med Sci 2019; 16(6):845-853. doi:10.7150/ijms.32505. https://www.medsci.org/v16p0845.htm
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Abstract

Background: Knee joint pain is the most common reason for physical disability which associates with age. TamaFlexTM (NXT15906F6) is a synergistic anti-inflammatory formulation which contains ethanol/aqueous extracts of Tamarindus indica seeds and ethanol extract of Curcuma longa rhizome.

Methods: In a 90-day randomized, double-blind, placebo-controlled study, we evaluated efficacy of NXT15906F6 in relieving pain and improving joint function in non-arthritic adults. Ninety non-arthritic subjects who experienced knee pain and joint discomfort following a six-minute walk test (SMWT) and Stair climb test (SCT) participated in the present trial. Subjects received either 250 mg (n=30) or 400 mg (n=30) of NXT15906F6 or matched placebo (PL: n=30) daily for 90 days. Improvement from baseline six-minute walk distance (SMWD) in NXT15906F6 groups, compared with placebo (PL) was the primary outcome of the study.

Results: At post-intervention, subjects in NXT15906F6-250 (p<0.001) and NXT15906F6-400 (p<0.0001) groups showed substantial improvements in mean changes of SMWD from baseline compared to placebo. The 250 mg and 400 mg NXT15906F6 groups also improved average walking speed from baseline by 0.08±0.07 m/s (p=0.0010) and 0.11±0.08 m/s (p<0.0001), respectively. The NXT15906F6 groups experienced significant improvement in SMWT performances as early as 14 days. NXT15906F6-supplemented participants showed a consistent benefit of pain relief and improved musculoskeletal functions, compared to placebo.

Conclusion: NXT15906F6 provided substantial relief from knee pain after physical activity and improved joint function in non-arthritic adults. Study participants did not show any major adverse events, and they tolerated well this novel herbal formulation.

Keywords: Knee joint pain, Musculoskeletal function, NXT15906F6, Six-minute walk test


Citation styles

APA
Rao, P.S., Ramanjaneyulu, Y.S., Prisk, V.R., Schurgers, L.J. (2019). A Combination of Tamarindus indica seeds and Curcuma longa Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity. International Journal of Medical Sciences, 16(6), 845-853. https://doi.org/10.7150/ijms.32505.

ACS
Rao, P.S.; Ramanjaneyulu, Y.S.; Prisk, V.R.; Schurgers, L.J. A Combination of Tamarindus indica seeds and Curcuma longa Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity. Int. J. Med. Sci. 2019, 16 (6), 845-853. DOI: 10.7150/ijms.32505.

NLM
Rao PS, Ramanjaneyulu YS, Prisk VR, Schurgers LJ. A Combination of Tamarindus indica seeds and Curcuma longa Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity. Int J Med Sci 2019; 16(6):845-853. doi:10.7150/ijms.32505. https://www.medsci.org/v16p0845.htm

CSE
Rao PS, Ramanjaneyulu YS, Prisk VR, Schurgers LJ. 2019. A Combination of Tamarindus indica seeds and Curcuma longa Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity. Int J Med Sci. 16(6):845-853.

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