Int J Med Sci 2013; 10(11):1530-1536. doi:10.7150/ijms.7256 This issue

Research Paper

Relationship between Plasma Fibrinogen Levels and Pulmonary Function in the Japanese Population: The Takahata Study

Yoko Shibata1✉, Shuichi Abe1, Sumito Inoue1, Akira Igarashi1, Keiko Yamauchi1, Yasuko Aida1, Hiroyuki Kishi1, Keiko Nunomiya1, Hiroshi Nakano1, Masamichi Sato1, Kento Sato1, Tomomi Kimura1, Takako Nemoto1, Tetsu Watanabe1, Tsuneo Konta1, Yoshiyuki Ueno2, Takeo Kato2, Takamasa Kayama2, Isao Kubota1

1. Department of Cardiology, Pulmonology, and Nephrology;
2. Global Center of Excellence Program Study Group, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
Shibata Y, Abe S, Inoue S, Igarashi A, Yamauchi K, Aida Y, Kishi H, Nunomiya K, Nakano H, Sato M, Sato K, Kimura T, Nemoto T, Watanabe T, Konta T, Ueno Y, Kato T, Kayama T, Kubota I. Relationship between Plasma Fibrinogen Levels and Pulmonary Function in the Japanese Population: The Takahata Study. Int J Med Sci 2013; 10(11):1530-1536. doi:10.7150/ijms.7256. Available from

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Background: Plasma fibrinogen is considered a biomarker of respiratory disease, owing to the relationship between plasma fibrinogen and pulmonary function established in Western populations. However, such a relationship has not yet been confirmed in an Asian population. We assessed this relationship in the general Japanese population.

Methods: Totally, 3,257 men and women aged ≥40 years who participated in a community-based annual health checkup in Takahata, Japan, from 2004 to 2006, underwent spirometry, and their plasma fibrinogen levels were determined.

Results: We found an inverse relationship between spirometric measures (percent predicted forced vital capacity [%FVC] and forced expiratory volume in 1s [%FEV1], and FEV1/FVC) and plasma fibrinogen levels in men, but not in women. The plasma fibrinogen levels were significantly higher in subjects with restrictive, obstructive, and mixed ventilatory disorders than in those with normal spirometry results. Multiple linear regression analysis revealed that in men, plasma fibrinogen levels were predictive for %FVC and %FEV1 (independent of age, body mass index, and cigarette smoking) but not for FEV1/FVC.

Conclusions: Plasma fibrinogen was significantly associated with pulmonary function in Japanese men, and as such, plasma fibrinogen might be a potent biomarker for pulmonary dysfunction in men.

Keywords: Chronic Obstructive Pulmonary Disease, Decline in FEV1, Fibrinogen, Pulmonary function, Smoker, Spirometry