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Int J Med Sci 2012; 9(6):467-471. doi:10.7150/ijms.4639 This issue Cite

Research Paper

Zn²⁺-SCMC Versus HA for Preventing Intraperitoneal Adhesions: A Rat Model Study

Xiaohong Du¹, Guanghui Hong², Pinghui Sun³, Guohui Liu^{4 ✉}

1. Departments of Hepatobiliary Surgery, the Norman Bethune First Hospital of Jilin University, Jilin 130021, China;
2. Departments of Anesthesiology, the Norman Bethune First Hospital of Jilin University, Jilin 130021, China;
3. Departments of Medical Statistics, the Norman Bethune First Hospital of Jilin University, Jilin 130021, China;
4. Departments of Emergency Surgery, the Norman Bethune First Hospital of Jilin University, Jilin 130021, China.

✉ Corresponding author: Dr. Guohui Liu, Emergency Surgery, the Norman Bethune First Hospital of Jilin University, Jilin 130021, China. Email: jlyuedu.cn. Tel: 86-0431-88782478; Fax: 86-0431-88782222.

Abstract

Background: Intraperitoneal adhesion is a serious surgical postoperative complication. Using a rat model, we compared the effectiveness of intraperitoneally administered zinc-modified sodium carboxymethyl cellulose (Zn²⁺-SCMC) and hyaluronic acid (HA) in preventing postoperative intraperitoneal adhesions.

Materials and Methods: Peritoneal adhesions were induced in 120 Wistar rats by scraping the cecal mucosa. The rats were randomized into a no treatment group (n = 40) or into a treatment group in which 3 ml of HA (n = 40) or Zn²⁺-SCMC (n = 40) was administered intraperitoneally before the abdominal wall was closed. Following sacrifice two weeks later, the intraperitoneal adhesions were scored and tissues were examined histologically using HE staining.

Results: Eight animals died, five in the untreated group (mortality rate, 12.5%), two in the HA group (mortality rate, 5.0%) and one in the Zn²⁺-SCMC group (mortality rate, 2.5%). Relative to the untreated group, the incidence of intraperitoneal adhesions was 77.5% in the HA and 48.7% in the Zn²⁺-SCMC group, with the incidence significantly lower in the Zn²⁺-SCMC group (P < 0.001). Both agents prevented intraperitoneal adhesions by promoting the repair of the abdominal serosa.

Conclusions: Administration of Zn²⁺-SCMC was more effective in preventing intraperitoneal adhesions than HA.

Keywords: Zn²⁺-SCMC, HA, intraperitoneal adhesion, abdominal surgery.

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