Int J Med Sci 2012; 9(5):334-338. doi:10.7150/ijms.4553 This issue

Research Paper

Expression of Glioma-associated Oncogene Homolog 1 is Associated with Invasion and Postoperative Liver Metastasis in Colon Cancer

Yin-lu Ding1, Yong Zhou1, Lei Xiang2, Zhi-peng Ji1✉, Zhou-hong Luo3✉

1. Department of General Surgery, the Second Hospital of Shandong University, Jinan , Shandong 250033, P.R. China.
2. Department of Pathology, School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China.
3. Laboratory of Electrocardiology, The Tumor Hospital of Xinjiang Medical University, Xinjiang 830000, P.R. China.

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Ding Yl, Zhou Y, Xiang L, Ji Zp, Luo Zh. Expression of Glioma-associated Oncogene Homolog 1 is Associated with Invasion and Postoperative Liver Metastasis in Colon Cancer. Int J Med Sci 2012; 9(5):334-338. doi:10.7150/ijms.4553. Available from

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Objective: To investigate the expression of glioma-associated oncogene homolog 1(Gli-1) in colon cancer and its association with clinicopathological parameters and postoperative liver metastasis.

Methods: Expression of Gli-1 was detected by immunohistochemistry in paraffin-embedded specimens of 96 cases of colon cancer. Relationship between Gli-1 expression and clinicopathological parameters, postoperative liver metastasis were analyzed.

Results: Gli-1 protein expression was significantly increased in colon cancer tissues compared to normal colon tissues (P = 0.037). Gli-1 expression in colon tissues was increased in patients with lymph node metastases (P = 0.022) and higher T stages (P = 0.030). Postoperative live metastasis-free survival period was significantly longer in low Gli-1 expression group than that of high Gli-1 expression group (48.22±10.03 months vs 20.46±6.32 months, P=0.001). Multivariate analysis showed that Gli-1 expression level is an independent prognostic factor for postoperative live metastasis-free survival.

Conclusion: Colon cancer is associated with an upregulation of Gli-1 protein expression in colon tissues. In patients with colon cancer, Gli-1 expression level is closely related to lymph node metastases, T stages and postoperative live metastasis-free survival periods, indicative of a possible role of Gli-1 expression in colon cancer progression.

Keywords: Colon neoplasm, Glioma-associated oncogene 1, Liver metastasis.