1. Department of Pulmonary Medicine, Konya Education and Research Hospital, Konya/ Turkey.
2. Department of Cardiology, Meram Medical Faculty, Selcuk University, Konya, Turkey.
3. Department of Biochemistry, Meram Medical Faculty, Selcuk University, Konya, Turkey.
4. Department of Pulmonary Medicine, Meram Medical Faculty, Selcuk University, Konya, Turkey.
Background: The mechanisms of the increased cardiac and vascular events in patients with OSA are not well understood. Arousal which is an important component of OSA was associated with increased sympathetic activation and electrocardiographic changes which prone to arrhythmias. We planned to examine the association among arousal, circulating Lp-PLA2 and total antioxidant capacity in male patients with OSA.
Methods: Fifty male patients with newly diagnosed OSA were enrolled the study. A full-night polysomnography was performed and arousal index was obtained. Lp-PLA2 concentrations were measured in serum samples with the PLAC Test. Total antioxidant capacity in patients was determined with Antioxidant Assay Kit.
Results: Arousal was positively correlated with LP-PLA2 levels (r=0.43, p=0.002) and was negatively correlated with total antioxidant capacity (r= -0.29, p=0.04). Elevated LP-PLA2 levels and decreased total antioxidant activities were found in the highest arousal quartile compared with the lowest and 2nd quartiles (p=0.02, p=0.05, respectively). LP-PLA2 was an independently predictor of arousal index in regression model (β=0.357, p=0.002)
Conclusions: This study demonstrated a moderate linear relationship between arousal and LP-PLA2 levels. Also, total antioxidant capacities were decreased in the higher arousal index. Based on the study result, the patients with higher arousal index may be prone to vascular events.
Keywords: Obstructive sleep apnea, Arousal, Lipoprotein-associated phospholipase A2, total antioxidant status, cardiovascular risk