Int J Med Sci 2007; 4(5):264-266. doi:10.7150/ijms.4.264 This issue Cite

Research Paper

Immunohistochemical Characteristics of Bone Forming Cells in Pleomorphic Adenoma

Keisuke Nakano1, 2, Takehiro Watanabe1, Takako Shimizu2, Toshiyuki Kawakami 1, 2

1. Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine, Shiojiri, Japan
2. Hard Tissue Pathology Unit, Matsumoto Dental University Institute for Oral Science, Shiojiri, Japan

Citation:
Nakano K, Watanabe T, Shimizu T, Kawakami T. Immunohistochemical Characteristics of Bone Forming Cells in Pleomorphic Adenoma. Int J Med Sci 2007; 4(5):264-266. doi:10.7150/ijms.4.264. https://www.medsci.org/v04p0264.htm
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Abstract

Histopathological and immunohistochemical examinations were carried out in a case of pleomorphic adenoma with bone formation, occurring in the chin of a 34-year-old Japanese man. Examination results showed the modified neoplastic myoepithelial cells reacted positively to S-100 protein. The S-100-positive modified neoplastic myoepithelial cells were proliferated in the closely related area of the bone tissue. Furthermore, positive reaction was detected in the bone forming cells: osteoblasts and osteocytes. These cells also reacted positively to Runx2 as a marker of bone forming cells. These results suggest that the origin of the bone forming cells in this case of pleomorphic adenoma was modified neoplastic myoepithelial cells.

Keywords: Bone forming cells, Immunohistochemical characteristics, Pleomorphic adenoma, Modified myoepithelial cell, Trans-differentiation


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APA
Nakano, K., Watanabe, T., Shimizu, T., Kawakami, T. (2007). Immunohistochemical Characteristics of Bone Forming Cells in Pleomorphic Adenoma. International Journal of Medical Sciences, 4(5), 264-266. https://doi.org/10.7150/ijms.4.264.

ACS
Nakano, K.; Watanabe, T.; Shimizu, T.; Kawakami, T. Immunohistochemical Characteristics of Bone Forming Cells in Pleomorphic Adenoma. Int. J. Med. Sci. 2007, 4 (5), 264-266. DOI: 10.7150/ijms.4.264.

NLM
Nakano K, Watanabe T, Shimizu T, Kawakami T. Immunohistochemical Characteristics of Bone Forming Cells in Pleomorphic Adenoma. Int J Med Sci 2007; 4(5):264-266. doi:10.7150/ijms.4.264. https://www.medsci.org/v04p0264.htm

CSE
Nakano K, Watanabe T, Shimizu T, Kawakami T. 2007. Immunohistochemical Characteristics of Bone Forming Cells in Pleomorphic Adenoma. Int J Med Sci. 4(5):264-266.

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