Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

Int J Med Sci 2024; 21(3):583-592. doi:10.7150/ijms.91571 This issue Cite

Research Paper

Association of sodium-glucose cotransporter 2 inhibitors with the incidence of corneal diseases in type 2 diabetes mellitus

Tsan-Yu Tsai1#, Po-Jen Yang2,3#, Shih-Chun Chao1,4,5, Chia-Yi Lee6,7,8, Jing-Yang Huang6,9, Shun-Fa Yang6,9✉, Hung-Yu Lin1,6,10,11✉

1. Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan.
2. Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
3. School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
4. Department of Optometry, Central Taiwan University of Science and Technology, Taichung, Taiwan.
5. Department of Optometry, Yuan Pei University, Hsinchu, Taiwan.
6. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
7. Department of Ophthalmology, Nobel Eye Institute, Taipei, Taiwan.
8. Department of Ophthalmology, Jen-Ai Hospital Dali Branch, Taichung, Taiwan.
9. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
10. Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
11. Department of Optometry, Chung Shan Medical University, Taichung, Taiwan.
# These authors contributed equally to this work.

✉ Corresponding authors: Shun-Fa Yang, Ph.D. or Hung-Yu Lin, MD, Ph.D., Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan; Tel: +886-4-24739595 ext. 34253; Fax: +886-4-24723229; E-mail: ysfedu.tw (Shun-Fa Yang); E-mail: More

Citation:
Tsai TY, Yang PJ, Chao SC, Lee CY, Huang JY, Yang SF, Lin HY. Association of sodium-glucose cotransporter 2 inhibitors with the incidence of corneal diseases in type 2 diabetes mellitus. Int J Med Sci 2024; 21(3):583-592. doi:10.7150/ijms.91571. https://www.medsci.org/v21p0583.htm
Other styles

File import instruction

Abstract

Graphic abstract

Sodium-glucose cotransporter 2 (SGLT2) inhibitors revealed the protective function on various systemic diseases. This study aimed to determine whether the usage of SGLT2 inhibitors associates with incidences of superficial keratopathy and infectious keratitis in type 2 diabetes mellitus (T2DM) patients. A retrospective cohort study with the usage of National Health Insurance Research Database of Taiwan was conducted. The T2DM patients were divided into the SGLT2 inhibitors and control groups according to the usage of SGLT2 inhibitors or not. The major outcomes were defined as the occurrence of superficial keratopathy and infectious keratitis. There were 766 and 1037 episodes of superficial keratopathy in the SGLT2 inhibitors and control groups and SGLT2 inhibitors group showed a significantly lower incidence of superficial keratopathy than the control group (aHR: 0.721, 95% CI: 0.656-0.791, P < 0.0001). Also, there were 166 and 251 infectious keratitis events in the SGLT2 inhibitors and control groups and patients in the SGLT2 inhibitors group revealed a significantly lower infectious keratitis incidence than those in the control group (aHR: 0.654, 95% CI: 0.537-0.796, P < 0.0001). In addition, the patients that received SGLT2 inhibitors demonstrated lower cumulative incidences of both superficial keratopathy and infectious keratitis compared to the non-SGLT2 inhibitors users (both P < 0.0001). In conclusion, the usage of SGLT2 inhibitors correlates to lower incidence of superficial keratopathy and infectious keratitis in T2DM individuals, which is more significant in patients with persistent SGLT2 inhibitors application.

Keywords: SGLT2 inhibitors, epidemiology, superficial keratopathy, infectious keratitis, age

Citation styles

APA
Tsai, T.Y., Yang, P.J., Chao, S.C., Lee, C.Y., Huang, J.Y., Yang, S.F., Lin, H.Y. (2024). Association of sodium-glucose cotransporter 2 inhibitors with the incidence of corneal diseases in type 2 diabetes mellitus. International Journal of Medical Sciences, 21(3), 583-592. https://doi.org/10.7150/ijms.91571.

ACS
Tsai, T.Y.; Yang, P.J.; Chao, S.C.; Lee, C.Y.; Huang, J.Y.; Yang, S.F.; Lin, H.Y. Association of sodium-glucose cotransporter 2 inhibitors with the incidence of corneal diseases in type 2 diabetes mellitus. Int. J. Med. Sci. 2024, 21 (3), 583-592. DOI: 10.7150/ijms.91571.

NLM
Tsai TY, Yang PJ, Chao SC, Lee CY, Huang JY, Yang SF, Lin HY. Association of sodium-glucose cotransporter 2 inhibitors with the incidence of corneal diseases in type 2 diabetes mellitus. Int J Med Sci 2024; 21(3):583-592. doi:10.7150/ijms.91571. https://www.medsci.org/v21p0583.htm

CSE
Tsai TY, Yang PJ, Chao SC, Lee CY, Huang JY, Yang SF, Lin HY. 2024. Association of sodium-glucose cotransporter 2 inhibitors with the incidence of corneal diseases in type 2 diabetes mellitus. Int J Med Sci. 21(3):583-592.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use