Int J Med Sci
2023; 20(12):1527-1534.
doi:10.7150/ijms.87978 This issueCite
Review
Critical Overview on Pure Chitosan-based Scaffolds for Bone Tissue Engineering: Clinical insights in Dentistry
Luca Signorini1,*, Gaetano Marenzi2,*, Anastasia Facente3,✉, Benedetta Marrelli3, Rosa Maria Marano3, Alessandra Valletta2, Luciano Pacifici4, Roberta Gasparro2,*, Gilberto Sammartino2,*, Marco Severino5,✉
1. Saint Camillus University of Health Science, 00100 Rome, Italy. 2. Department of Neurosciences, Reproductive and Odontostomatological Sciences, Postgraduate School of Oral Surgery, University “Federico II” of Naples, via S. Pansini 5, 80131 Naples, Italy. 3. Tecnologica Research Institute - Marrelli Health, 88900 Crotone, Italy. 4. Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, 00195 Rome, Italy. 5. Department of Medicine and Surgery, University of Perugia, Italy. *Co-contributing authors
✉ Corresponding author: Dr. Anastasia Facente. researchcom.
Citation:
Signorini L, Marenzi G, Facente A, Marrelli B, Marano RM, Valletta A, Pacifici L, Gasparro R, Sammartino G, Severino M. Critical Overview on Pure Chitosan-based Scaffolds for Bone Tissue Engineering: Clinical insights in Dentistry. Int J Med Sci 2023; 20(12):1527-1534. doi:10.7150/ijms.87978. https://www.medsci.org/v20p1527.htm
Bone Tissue Engineering (BTE) is a field of regenerative medicine continuously improving, thanks to the development of new biomaterials used as grafts or scaffolds for repairing bone defects. In recent years, chitosan, a natural biopolymer extracted mainly from crustacean shells, has demonstrated unique and desirable characteristics for BTE applications, such as: biocompatibility, biodegradability, and osteoconductive behavior. Additionally, the presence of numerous active amine groups in its chemical structure allows it to be easily modified. Data suggest that chitosan scaffolds are highly biomimetic, and show an interesting bioactivity, and antibacterial behavior. We have demonstrated, in a critical overview, how chitosan-based scaffolds may hold great interest for BTE applications in medical and dental applications. Future research should be focused on the use of chitosan-scaffolds combined with other biomaterials or bioactive molecules, to increase their overall regenerative potential, also in critical-sized defects. In conclusion, chitosan can be considered a promising biomaterial in BTE and clinical dentistry.
Citation styles
APA
Signorini, L., Marenzi, G., Facente, A., Marrelli, B., Marano, R.M., Valletta, A., Pacifici, L., Gasparro, R., Sammartino, G., Severino, M. (2023). Critical Overview on Pure Chitosan-based Scaffolds for Bone Tissue Engineering: Clinical insights in Dentistry. International Journal of Medical Sciences, 20(12), 1527-1534. https://doi.org/10.7150/ijms.87978.
ACS
Signorini, L.; Marenzi, G.; Facente, A.; Marrelli, B.; Marano, R.M.; Valletta, A.; Pacifici, L.; Gasparro, R.; Sammartino, G.; Severino, M. Critical Overview on Pure Chitosan-based Scaffolds for Bone Tissue Engineering: Clinical insights in Dentistry. Int. J. Med. Sci. 2023, 20 (12), 1527-1534. DOI: 10.7150/ijms.87978.
NLM
Signorini L, Marenzi G, Facente A, Marrelli B, Marano RM, Valletta A, Pacifici L, Gasparro R, Sammartino G, Severino M. Critical Overview on Pure Chitosan-based Scaffolds for Bone Tissue Engineering: Clinical insights in Dentistry. Int J Med Sci 2023; 20(12):1527-1534. doi:10.7150/ijms.87978. https://www.medsci.org/v20p1527.htm
CSE
Signorini L, Marenzi G, Facente A, Marrelli B, Marano RM, Valletta A, Pacifici L, Gasparro R, Sammartino G, Severino M. 2023. Critical Overview on Pure Chitosan-based Scaffolds for Bone Tissue Engineering: Clinical insights in Dentistry. Int J Med Sci. 20(12):1527-1534.
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