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Int J Med Sci 2023; 20(2):225-231. doi:10.7150/ijms.80262 This issue Cite

Review

Research progress of PBX1 in developmental and regenerative medicine

Hao Chen1*, Zhuyuan Yu1*, Ye Niu2, Litian Wang1, Kan Xu1✉, Jinyu Liu2✉

1. Department of Neurovascular Surgery, First Hospital of Jilin University, 1 Xinmin Avenue Changchun 130021, Jilin Province, China.
2. Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China.
* Hao Chen and Zhuyuan Yu have contributed equally to this work.

✉ Corresponding authors: Jinyu Liu (Electronic address: jy_liuedu.cn), Kan Xu (Electronic address: xukanedu.cn).

Citation:
Chen H, Yu Z, Niu Y, Wang L, Xu K, Liu J. Research progress of PBX1 in developmental and regenerative medicine. Int J Med Sci 2023; 20(2):225-231. doi:10.7150/ijms.80262. https://www.medsci.org/v20p0225.htm
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Abstract

Graphic abstract

Pre-B-cell leukemia transcription factor 1 (PBX1) proteins are a subfamily of evolutionarily conserved atypical homeodomain transcription factors belonging to the superfamily of triple amino acid loop extension homeodomain proteins. PBX family members play crucial roles in the regulation of various pathophysiological processes. This article reviews the research progress on PBX1 in terms of structure, developmental function, and regenerative medicine. The potential mechanisms of development and research targets in regenerative medicine are also summarized. It also suggests a possible link between PBX1 in the two domains, which is expected to open up a new field for future exploration of cell homeostasis, as well as the regulation of endogenous danger signals. This would provide a new target for the study of diseases in various systems.

Keywords: Pbx1, Development, Regenerative medicine, Transcription factors

Citation styles

APA
Chen, H., Yu, Z., Niu, Y., Wang, L., Xu, K., Liu, J. (2023). Research progress of PBX1 in developmental and regenerative medicine. International Journal of Medical Sciences, 20(2), 225-231. https://doi.org/10.7150/ijms.80262.

ACS
Chen, H.; Yu, Z.; Niu, Y.; Wang, L.; Xu, K.; Liu, J. Research progress of PBX1 in developmental and regenerative medicine. Int. J. Med. Sci. 2023, 20 (2), 225-231. DOI: 10.7150/ijms.80262.

NLM
Chen H, Yu Z, Niu Y, Wang L, Xu K, Liu J. Research progress of PBX1 in developmental and regenerative medicine. Int J Med Sci 2023; 20(2):225-231. doi:10.7150/ijms.80262. https://www.medsci.org/v20p0225.htm

CSE
Chen H, Yu Z, Niu Y, Wang L, Xu K, Liu J. 2023. Research progress of PBX1 in developmental and regenerative medicine. Int J Med Sci. 20(2):225-231.

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