Int J Med Sci 2023; 20(1):50-56. doi:10.7150/ijms.79496 This issue Cite

Research Paper

Effects of Long-Term Wear and Discontinuation of Orthokeratology Lenses on the Eyeball Parameters in Children with Myopia

Qin Zhu1,2*, Jie Yin2*, Xuejiao Li2*, Min Hu2, Liping Xue2, Jieying Zhang2, Yuan Zhou2, Xiaofan Zhang2, Yingting Zhu3✉, Hua Zhong1✉

1. Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, Kunming 650031, China.
2. Department of Pediatric Ophthalmology, Affiliated Hospital of Yunnan University; Kunming 650021, China.
3. BioTissue (Tissue Tech, Inc.), Ocular Surface Center, and Ocular Surface Research & Education Foundation, Miami, FL, 33126 USA.
* The first 3 authors contribute equally for this manuscript.

Citation:
Zhu Q, Yin J, Li X, Hu M, Xue L, Zhang J, Zhou Y, Zhang X, Zhu Y, Zhong H. Effects of Long-Term Wear and Discontinuation of Orthokeratology Lenses on the Eyeball Parameters in Children with Myopia. Int J Med Sci 2023; 20(1):50-56. doi:10.7150/ijms.79496. https://www.medsci.org/v20p0050.htm
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Abstract

Graphic abstract

Objective: To evaluate the effects of long-term wear and discontinuation of the orthokeratology lenses (Orth-K) on the biological parameters of eyeballs in children with myopia.

Methods: In this prospective study, a total of 308 subjects with myopia were randomized to receive Orth-K (n = 154) or single vision spectacles (SVS) (n = 154) for 12 months followed by a 1-month withdrawal period. The axial length (AL), the central corneal thickness (CCT), the anterior chamber depth (ACD) and the central lens thickness (CLT) were assessed at the baseline, 6 months, 12 months, and 13 months (1-month after lens withdrawal).

Results: A total of 279 subjects completed the 13-month follow-up (142 in Orth-K group and 137 in SVS group). No statistical difference was noted in AL, CCT, ACD and CLT between the two groups at the baseline (all p > 0.05). However, compared with the baseline, the AL from the two groups became elongated 12 months after wearing Orth-K or SVS. The increase of AL in Orth-K group was 0.22 ± 0.11 mm, significantly smaller than 0.35 ± 0.08 mm in SVS group (p < 0.05). In addition, CCT in Orth-K group was 544.26 ± 11.69 µm at 12 months, significantly thinner than 550.49 ± 12.13 µm in SVS group (p < 0.05). Interestingly, the change in CCT between the baseline and 1-month after withdrawal of the lens was not statistically different in either group (all p > 0.05). Furthermore, at 12-months, CLT in Orth-K group was 3.35 ± 0.21 mm, significantly thicker than 3.31 ± 0.15 mm at baseline and thicker than 3.30 ± 0.05 mm in SVS group at 12 months (all p < 0.05). Lastly, ACD was not statistically different between Orth-K and SVS groups at any time point (p > 0.05).

Conclusion: Orthokeratology lenses can effectively retard axial elongation, reversibly reduce CCT, increase CLT in myopic children, but have no obvious effect on ACD, indicating that Orth-K may significantly retard myopia without noticeable myopia rebound after interruption of Orth-K.

Keywords: myopia, children, orthokeratology, axial length, central corneal thickness, anterior chamber depth, central lens thickness


Citation styles

APA
Zhu, Q., Yin, J., Li, X., Hu, M., Xue, L., Zhang, J., Zhou, Y., Zhang, X., Zhu, Y., Zhong, H. (2023). Effects of Long-Term Wear and Discontinuation of Orthokeratology Lenses on the Eyeball Parameters in Children with Myopia. International Journal of Medical Sciences, 20(1), 50-56. https://doi.org/10.7150/ijms.79496.

ACS
Zhu, Q.; Yin, J.; Li, X.; Hu, M.; Xue, L.; Zhang, J.; Zhou, Y.; Zhang, X.; Zhu, Y.; Zhong, H. Effects of Long-Term Wear and Discontinuation of Orthokeratology Lenses on the Eyeball Parameters in Children with Myopia. Int. J. Med. Sci. 2023, 20 (1), 50-56. DOI: 10.7150/ijms.79496.

NLM
Zhu Q, Yin J, Li X, Hu M, Xue L, Zhang J, Zhou Y, Zhang X, Zhu Y, Zhong H. Effects of Long-Term Wear and Discontinuation of Orthokeratology Lenses on the Eyeball Parameters in Children with Myopia. Int J Med Sci 2023; 20(1):50-56. doi:10.7150/ijms.79496. https://www.medsci.org/v20p0050.htm

CSE
Zhu Q, Yin J, Li X, Hu M, Xue L, Zhang J, Zhou Y, Zhang X, Zhu Y, Zhong H. 2023. Effects of Long-Term Wear and Discontinuation of Orthokeratology Lenses on the Eyeball Parameters in Children with Myopia. Int J Med Sci. 20(1):50-56.

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