Int J Med Sci 2022; 19(6):1082-1092. doi:10.7150/ijms.72621 This issue

Review

Crucial Roles of LncRNAs-Mediated Autophagy in Breast Cancer

Xinwei Han1,2*, Jinggang Mo1*, Yingmei Yang1, Yichao Wang1✉, Hongsheng Lu1✉

1. Tai Zhou Central Hospital (Taizhou University Hospital), No.999 Donghai Road, Jiaojiang District, Taizhou, Zhejiang, 318000, China.
2. Cytotherapy Laboratory, Shenzhen People's Hospital, 1017, Dongmen North Road, Luohu, Shenzhen, 518020, China.
*These authors contributed equally to this work.

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Citation:
Han X, Mo J, Yang Y, Wang Y, Lu H. Crucial Roles of LncRNAs-Mediated Autophagy in Breast Cancer. Int J Med Sci 2022; 19(6):1082-1092. doi:10.7150/ijms.72621. Available from https://www.medsci.org/v19p1082.htm

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Abstract

Graphic abstract

Breast cancer remains a worldwide public health issue. LncRNA and autophagy respectively or simultaneously, get involved in cellular and molecular processes of many different cancers, including genesis, metastasis, and deterioration of breast cancer and other malignant tumors. In this review, relevant studies have been summarized, and we have found that lncRNA-mediated autophagy in luminal A breast cancer, luminal B breast cancer, HER-2 positive breast cancer, and basal-like breast cancer may play an important role in mediating drug resistance sensitivity. LncRNAs target genes and affect different signaling pathways to a complex network, which attenuates the occurrence and development of primary breast cancer by coordinating autophagy. Abnormal expression of LncRNA may lead to dysregulation of autophagy, resulting in tumor genesis, expansion, and resistance to anti-tumor therapy. Targeting specific lncRNAs for autophagy regulation may conduct as a bio-marker for reliable diagnosis and prognosis treatment of breast cancer or provide a promising therapeutic strategy.

Keywords: LncRNA, Autophagy, Molecular mechanisms, Breast cancer, Drug resistance