Int J Med Sci 2022; 19(5):952-964. doi:10.7150/ijms.62438 This issue

Research Paper

In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft

Lijun Zhang1,2,#, Guangchao Xu1,#, Yating Wei1, Mingzhou Yuan2, Yuanyuan Li1,2, Meifang Yin1,2, Chufen Chen2, Guangtao Huang1, Bin Shu2,✉, Jun Wu1,2,3✉

1. Department of Burns and Plastic Surgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, P.R. China.
2. Department of Burns, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P.R. China.
3. Human Histology & Embryology Section, Department of Surgery, Dentistry, Pediatrics & Gynecology, University of Verona Medical School, Italy.
# Equal contribution.

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Citation:
Zhang L, Xu G, Wei Y, Yuan M, Li Y, Yin M, Chen C, Huang G, Shu B, Wu J. In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft. Int J Med Sci 2022; 19(5):952-964. doi:10.7150/ijms.62438. Available from https://www.medsci.org/v19p0952.htm

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Abstract

Graphic abstract

Preventing fibrosis or hypertrophic scar formation following tissue damage is still a big challenge despite the numerous approaches clinicians currently use. Hitherto, no written account was available of a successful case of scarless skin healing after a severe burn injury. Here, we report the first case of the “perfect regenerative healing” of a severe burn wound with no hypertrophic scar formation in which a postage stamp skin autograft was covered with human cytotoxic-T-lymphocyte associated antigen4-immunoglobulin (hCTLA4Ig) gene-transferred pig skin. We also discuss the mechanisms involved in the scarless healing of human burn wounds.