Int J Med Sci 2022; 19(5):941-951. doi:10.7150/ijms.72529 This issue

Research Paper

Grape seed powder increases gastrointestinal motility

Na Ri Choi1, Jeong Nam Kim1, Min Ji Kwon1, Jong Rok Lee2, Sang Chan Kim3, Min Jae Lee4, Woo-gyun Choi1,✉, Byung Joo Kim1,✉

1. Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan 50612, Republic of Korea.
2. Department of Pharmaceutical Engineering, Daegu Haany University, Gyeongsan 38610, Republic of Korea.
3. College of Oriental Medicine, Daegu Haany University, Gyeongsan 38610, Republic of Korea.
4. College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.

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Choi NR, Kim JN, Kwon MJ, Lee JR, Kim SC, Lee MJ, Choi Wg, Kim BJ. Grape seed powder increases gastrointestinal motility. Int J Med Sci 2022; 19(5):941-951. doi:10.7150/ijms.72529. Available from

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Graphic abstract

Grape seed is an important natural bioactive product with various health benefits. Interstitial cells of Cajal (ICCs) are pacemaker cells in the gastrointestinal (GI) tract. The present study investigated the effects of grape seed powder (GSP) on ICC properties and GI motility. GSP depolarized the pacemaker potentials of ICCs in a dose‑dependent manner. Y25130 or SB269970 slightly inhibited GSP‑induced effects. However, Y25130 and SB269970 together completely blocked GSP-induced effects. In the presence of inhibitors of protein kinase C, protein kinase A, or mitogen-activated protein kinase, GSP‑induced ICC depolarization was inhibited. GSP increased the intestinal transit rate in normal mice and in mice with acetic acid-induced GI motility disorder. In addition, the levels of motilin and substance P were elevated after GSP dosing. These results demonstrate that GSP can regulate GI motility, and therefore, it is a potential therapeutic agent for treating GI motility disorders.

Keywords: Grape seed, Bioactive product, Interstitial cell of Cajal, Gastrointestinal motility, ICC