Int J Med Sci 2021; 18(15):3498-3505. doi:10.7150/ijms.60728 This issue

Research Paper

Expression and localization of Sox10 during hair follicle morphogenesis and induced hair cycle

Jing Jing1, Peng Xu2, Jia-Li Xu1, Yu-Xin Ding1, Xiao-Shuang Yang1, Xiao-Qin Jin3, Li-Juan Zhou4, Yu-Hong Chen1, Xian-Jie Wu1, Zhong-Fa Lu1✉

1. Department of Dermatology, the second affiliated hospital of Zhejiang University, Hangzhou 310000, China.
2. Department of Neuro intensive Care Unit, the second affiliated hospital of Zhejiang University, Hangzhou 310000, China.
3. Zhejiang Chinese Medical University, Hangzhou 310000, China.
4. Department of Dermatology, Huashan Hospital Fudan University, Shanghai 200000, China.

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Citation:
Jing J, Xu P, Xu JL, Ding YX, Yang XS, Jin XQ, Zhou LJ, Chen YH, Wu XJ, Lu ZF. Expression and localization of Sox10 during hair follicle morphogenesis and induced hair cycle. Int J Med Sci 2021; 18(15):3498-3505. doi:10.7150/ijms.60728. Available from https://www.medsci.org/v18p3498.htm

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Abstract

Graphic abstract

Sox transcription factors play many diverse roles during development, including regulating stem cell states, directing differentiation, and influencing the local chromatin landscape. Sox10 has been implicated in the control of stem/progenitor activity and epithelial-mesenchymal transition, yet it has not been studied in relation to the hair follicle cycle or hair follicle stem cell (HFSC) control. To elucidate the role of Sox10 in hair follicle cycle control, we performed immunohistochemical and immunofluorescence analysis of its expression during hair morphogenesis, the postnatal hair cycle, and the depilation-induced murine hair follicle cycle. During hair follicle morphogenesis, Sox10 was expressed in the hair germ and peg. In telogen, we detected nuclear Sox10 in the hair bulge and germ cell cap, where HFSCs reside, while in anagen and catagen, Sox10 was detected in the epithelial portion, such as the strands of keratinocytes, the outer root sheath (ORS) in anagen, and the regressed epithelial strand of hair follicle in catagen. These results suggest that Sox10 may be involved in early hair follicle morphogenesis and postnatal follicular cycling.

Keywords: Sox10, hair follicle stem cell, morphogenesis