Int J Med Sci 2021; 18(13):2943-2949. doi:10.7150/ijms.60874 This issue


Designing Nanoparticle-based Drug Delivery Systems for Precision Medicine

Jianhua Yang1, Chengyou Jia2, Jianshe Yang2,3✉

1. Department of Orthopaedics, Longgang District People's Hospital, Shenzhen 518172, China.
2. Shanghai Research Center for Thyroid Diseases, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
3. Health and Life Science College, the Chinese University of Hong Kong, Shenzhen 518172, China.

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Yang J, Jia C, Yang J. Designing Nanoparticle-based Drug Delivery Systems for Precision Medicine. Int J Med Sci 2021; 18(13):2943-2949. doi:10.7150/ijms.60874. Available from

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Graphic abstract

Traditional drugs are facing bottlenecks of lower solubility, absorption, and especially the inefficient organs or cells targeting during the precision medicine era. It is urgently needed to discover and establish new methods or strategies to modify old drugs or create new ones against the above defects. With the support of nanotechnology, the solubility, absorption and targeting of traditional drugs were greatly improved by modifying and fabricating with various types of nanoparticles to some extent, though many shortages remain. In this mini-review we will focus on advances in several most commonly used nanoparticles, from their nature and design, to drug delivery system and clinical application, that they overcome heterogeneous barriers in precision medicine, thereby ultimately improve patient outcome overall.

Keywords: nanoparticles, drug delivery system, precision medicine, drug design